Modeling the Inflammatory Response to Bacterial Lipopolysaccharide

1
Modeling the Inflammatory Response to Bacterial
Lipopolysaccharide

• Kaja Abbas
• Joanna González-Lergier
• René Ott
• Mohamed Uduman
• Shlomo Taasan and Emrah Diril

2
LPS Triggered Cytokine Release Experimental Setup
3
LPS Triggered Cytokine Release Experimental Data
4
Model of LPS Infection
5
Model of LPS Infection
6
Differential Equations
7
Model Predictions
8
TNFa Model Predictions
9
IL6 Model Predictions
10
IL10 Model Predictions
11
Parameter Optimization
12
Model Results from Literature
Vodovotz et al SHOCK 2005.
13
Future Steps

• 1. Investigate effect of different
  concentrations of LPS on model.
• Optimization of Parameters
• ? Optimize cytokines individually.
• ? Use of a different model?
• Validation of model through measurement of
  intracellular concentrations.
• 4. More literature research on signaling from
  LPS to cytokine secretion.

14
(No Transcript)