Computational Cardiac Modeling Abroad

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Computational Cardiac Modeling Abroad
Prime 2006 Progress Report 4

• Iwen Wu August 11, 2006
• Monash University, Australia

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Progress

• Nimrod G
• Refined parameters on Nimrod to do additional
  runs with more stable parameters
• Sorted through resulting graphs for endocardial,
  epicardial and midmyocardial cells to find most
  stable one so far
• Nimrod O
• Modified program to give a regression value for
  the last ten periods of a 50 second trial and
  saves it as a squared value to eliminate
  negatives
• Sum of all the squared slope values for the four
  concentrations in each cell is saved to a text
  file that will give an relative overall estimate
  of stability for all four graphs
• Did a run through Nimrod O to randomly sample
  combinations in the specified parameter space to
  optimize the sum to as close to zero as possible

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Final Goals

• Make sure the returned regression value for
  stability is accurate
• Obtain results from the Nimrod O experiment to
  see if it can give a better idea of what the
  optimal parameters should be
• Get a final set of parameters for each cell that
  will stabilize Cai, CaSR, Nai, and Kai
  concentrations over 50 seconds
• Compare with data from Cordiero and Tusscher
  papers to ensure that the models are
  physiologically accurate

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