ATP Production from Fuel Oxidation

1
ATP Production from Fuel Oxidation

• Dr. Kieron Rooney
• K120.
• K.Rooney_at_fhs.usyd.edu.au

2
Fuel Oxidation is coupled to ATP resynthesis in
the Mitochondria.
H
H
H
H
H
H
Electron Transport Chain
IV
Matrix
ATPsynthase also called F1FoATPase
H2O
½O2 2H
H
H
ATP
H
ADP
3
The Electron Transport Chain is the link.
4
The TCA cycle supplies the ETC?

• Acetyl CoA 3NAD FAD GDP Pi 2H2O
• ? 2CO2 3NADH FADH2 GTP 2H CoA

5
Where does the Acetyl CoA come from?

• The Oxidation of Carbohydrates and Fats
• Pyruvate CoA NAD ? Acetyl CoA CO2 NADH
• Glucose 2Pi 2 ADP 2 NAD ? 2 Pyruvate 2
  ATP 2 NADH 2 H 2 H2O

6
Glucose
6
HOCH2
5
O
H
H
H
4
H
OH
1
3
2
OH
HO
OH
H
7
Fatty Acids are broken down into Acetyl CoA Units
1
n 1
2
3
4 to n
? - Carbon
? - Carbon
? (omega) - Carbon
Palmitate
8
Glycogen is the natural store of glucose
9
Triglyceride is the natural store of Fatty Acids
CH3(CH2)14COOH

CH3(CH2)7CH CH(CH2)7COOH
CH3(CH2)16COOH
Glycerol
3 Fatty Acids
H2COOC(CH2)14CH3
CH3(CH2)7CH CH(CH2)7COOCH
H2COOC(CH2)16CH3

3H20
10
ATP Production??

• GLUCOSE
• C6H12O6 6O2 36 ADP
• ? 6 CO2 36 ATP 42H2O
• PALMITATE
• C16H32O2 23O2 129ADP
• ? 16CO2 129ATP 145H2O

11
Respiratory Exchange Ratio (RER) / Respiratory
Quotient (RQ)

• VO2 VOLUME OF OXYGEN CONSUMED
• VCO2 VOLUME OF CARBON DIOXIDE PRODUCED
• Together, we can get an assessment of the RQ..
• RESPIRATORY QUOTIENT (RQ) VCO2 / VO2
• GLUCOSE 6 / 6 FAT 16 / 23
• 1 0.696
• PROTEIN 0.818