FQPA: Its a Good Thing for Kids

1
FQPAIts a Good Thing(for Kids)

• Penelope A. Fenner-Crisp, PhD, DABT
• (USEPA, retired)
• Presented at the 2007 Society of Toxicology
• Regulatory and Safety Evaluation Specialty
  Section
• Charlotte, NC
• March 26, 2007

2
Why?

• Implementation of the FQPA directives is leading
  to a reduction in exposure to pesticides
  possessing a greater degree of hazard concern

3
Reminder

• FQPA FIFRA FFDCA

4
FFDCA

• When setting or (re)assessing tolerances, EPA is
  to
• Apply an extra 10X safety factor to assure the
  protection of infants and children
• Assess total pesticide exposure from all
  non-occupational sources diet, drinking water,
  residential and other non-occupational sources
• Assess effects of exposure to multiple pesticides
  with a common mechanism of toxicity

5
Impact of Kids Safety Factor

P A D

R f D
1X
3X
10X
Size of Safety Factor
Population Adjusted Dose
6
Impact of Aggregate Assessment
The Risk Cup the PAD
R
R
F
DW
DW
R
F

F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
R
F
F
F
F
Food residues (F) alone (pre-FQPA)
Food Residues (F) Drinking Water Residues (DW)
Food residues (F) Drinking Water Residues (DW)
Residential Residues (R)
7
Impact of Cumulative Assessment
R
R
R
F
R
R
R
R
R
R
R
R
DW
F
F
DW
R
F
R
R
R
F
F
F
F
F
F
DW
T
F
F
F

F
F
F
R
F
F
F
F
R
F
F
R
F
8
Cumulative Risk Assessment Decisions

• Chlorinated triazines (3) and Chloroacetanilides
  (2) meet safety standard
• Organophosphates
• From gt 40 in 1996 to 32 today
• Cancelled/phased out substantial number of
  residential uses
• Cancelled/phased out gt 50 uses on kids foods

9
FIFRA

• Tolerance Reassessment
• Reregistration
• Expedited Review for Reduced Risk Pesticides
• Registration Renewal

10
FIFRA-Tolerance Reassessment

• All existing tolerances to be reassessed by
  August 3, 2006
• Accomplishments as of August 2006
• Focused on the Worst First OPs, Carbamates,
  Group B, Cq carcinogens, RfD exceeders, high
  hazard inerts
• Completed assessment of 9637 of 9721 tolerances
  for 470 food use pesticides and high hazard
  inerts
• Recommended revocation of 3200 tolerances
• Recommended modification of 1200 tolerances
• Confirmed safety of 5237 tolerances

11
FIFRA-Reregistration

• FQPA mandated completion of reregistration (for
  the fourth time)
• Accomplishments as of August 3, 2006
• Completed 559 of 566 reregistration eligibility
  decisions for food-use pesticides
• Remaining 54 non-food use cases to be completed
  by October, 2008.
• 4400 of 17,600 individual pesticide end-use
  product registrations cancelled

12
FIFRA-Reduced Risk Pesticides

• FQPA formalized 1992/3 guidance for expedited
  registration review of reduced risk (RR)
  conventional pesticides
• Areas of criteria supporting definition of RR
• Human Health
• Non-target organisms (birds and fish)
• Potential for groundwater contamination
• Lower use rates, less frequent application
• Low pest resistance potential
• Compatibility with IPM
• Efficacy

13
RR Human Health Effects Factors

• Very low mammalian toxicity
• Toxicity generally lower than alternative
  (10-100x)
• Displaces chemicals that pose high concern (e.g.,
  the OPs, Probable carcinogens)
• Reduces exposure in occupational settings

14
RR Pesticide Actions1994-2006

• Number of active ingredients reviewed 70
• Number of new actives 47
• Number of OP alternatives 28
• Number of new uses granted 668
• Number of new uses granted for OP alternatives
  260

1999- first year of expedited review of OP
Alternatives
15
FIFRA-Registration Renewal

• FQPA mandates periodic review of pesticide
  registration
• 15-year review cycle
• Procedural regulations in place (August, 2006)
• Schedule for FY07-FY10 issued (October, 2006)
• Covers conventional, antimicrobial, biochemical,
  microbial pesticides

16
Im Maggie. Im 2 weeks old
Im Drew. Im 11 years old Our Grandma
says that FQPA is a good thing for infants and
kids like us.