Pr

1
APP therapeutic target
N-ter
Neuroprotection against tauopathy
sAPP beta
APP
1 Abeta oligomers
2b Beta secretase (BACE1)
Extracellular domain
3 Alpha secretase
No Abeta formation
Abeta
Gamma secretase
Gamma secretase 2a
4 Turn- over
Alpha stub
C-ter
AICD ? transcription factor neprilysin,
Beta stub
AICD ?
Intracellular domain
Amyloidogenic pathway the evil
Non-amyloidogenic pathway the good