Mathematical and computational modeling of intracellular signaling pathways

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Project Ran-GTP gradients during mitosis
Mathematical and computational modeling of
intracellular signaling pathways Pablo A.
Iglesias, PhD Electrical Computer and
Biomedical Engineering, Applied Math
Stats www.ece.jhu.edu/pi pi_at_jhu.edu
Project Gradient sensing models
Shown is the concentration gradient of Ran-GTP
produced by a mitotic cell. It demonstrates that
the greatest concentrations appear in
intra-chromosomal areas.
Project Modeling cytoskeletal dynamics during
chemotaxis and cytokinesis
We model the cell-shape changes induced by both
intra and extracellular cues
This figure shows the response of a model of
gradient sensing in Dictyostelium to a
combination of spatial and temporal inputs. The
cellular response is shown for comparison