Dimension Lynx Presentation

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Chemistry Evolution Dade Behring Dimension Lynx
Syst David Tshiporo .
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The Dimension Lynx System
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(No Transcript)
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Laboratory Process Overview
Pre-Analytical
Post-Analytical
test order
sample collection
storage retrieval
transport to lab
result release
process sample
result interpretation
sample analysis
Analytical
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Pre-Analytical Challenges

• Sample Collection
• Tube type
• "Plasma for this...serum for that"
• Multiple tubes drawn based on instrument
  configurations
• Chemistry analyzer - BMP's
• Immunoassay analyzer - Troponin
• Specialty analyzer - HbA1C
• Time, Labor Supplies
• Additional time taken to draw 2 tubes vs. 1 tube
• Additional supplies used
• Impact on sample tube delivery
• Transport to Lab
• "Collect to Receive"

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Pre-Analytical Challenges

• Process Sample
• Receive
• Manual process based on number of tubes
• Sort
• Department, Tube Type, Stat vs. Routine
• Centrifuge
• Decap
• Repetitive manual process
• Aliquot/Send-outs
• Daughter tube
• Label
• Pour Off
• Transport
• Delivery to various workstations

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Analytical Challenges

• Sample Analysis
• Determine which analyzer sample should be run on
• What tests are configured on what analyzer
• Is the analyzer calibrated
• Has QC been performed
• Is the analyzer already running tests
• Which analyzer will provide best TAT
• What happens if one analyzer is off-line
• Do I have enough sample
• Does the sample have a clot

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Post-Analytical Challenges

• Result Interpretation
• Do I need to re-run the sample?
• Outside panic range
• Outside linear range
• Does the result require reflex testing?
• What is the impact of HIL on the result?
• Results Release
• Manually releasing test results to LIS
• Storage Retrieval
• Where do we store the sample what in which
  order
• Finding the darn sample for reuse

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Laboratory Process Overview
Pre-Analytical
Post-Analytical
test order
sample collection
storage retrieval
transport to lab
result release
process sample
result interpretation
sample analysis
Analytical
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Dimension Lynx System
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INTEGRATED
AUTOMATED
FLEXIBLE
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Sample Management Module

• Centralized operation for the whole system
• "Links" two Dimension RxL Max instruments
  together
• "Links" one Dimension RxL Max instrument and one
  DPC Immulite instrument together
• View each Dimension from one common monitor
• The beauty of the Dimension Lynx...One Operator!

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Sample Loading Delivery

• Sample Rack
• Standard Rack 48 tube capacity
• Priority Rack 12 tube capacity
• Sample Rack Lanes
• 12 standard rack input/output lanes
• 2 priority rack input lanes
• 2 priority rack output lanes
• 600 Sample Tube load capacity
• Simultaneous processing of a wide variety of tube
  types and sizes
• Sample Throughput 300 tubes/hr

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Sample Decapping

• Works w/stopper and screw-cap tubes
• Able to use a range of tube sizes from various
  manufacturers
• Reduced contact with potential bio-hazards
• Compact, dependable design
• Reduces manual repetitive processes

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Sample Transfer Module

• True clot detection
• Outstanding sample level sensing
• Delivers sample aliquot from primary tube to
  aliquot segment
• Aliquot segment
• Contain 63 wells/segment
• Holds 12 segments
• 756 sample capacity
• Quick release of primarytube to the Sample
  Management Module for further needs

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an excellent example of purposeful
innovation and intelligent evolution

• First to introduce Chemistry/Immuno testing on a
  single integrated platform!
• Excellent footprint for a high volume analyzer
• Simple, one-touch operation
• 1 selling analyzer for the past six years in a
  row

in the US market - 2005 Information Dynamics
Market Monitor Report
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QuikLYTE IMT System

• Fast and Easy
• Integrated sensor for Na, K, Cl-
• Sample result in 36 seconds
• True Automatic calibration
• No external calibration required by the
  operator!!!
• Stability and Reliability
• Indirect Potentiometry
• Small sample volume - 40 µL
• Ready to use No maintenance
• Stability 5 days

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Immunoassay Module

• Advanced Technology
• CrO2 (no magnetic resonation)
• Enzymatic cascade highly sensitive, fast
• 1 or 2 step heterogeneous sandwich assays
• High throughput 336 tests/hour
• Time to first result 16 - 18 minutes
• Concurrent Analysis

Dual Dimension RxL Max Suite configuration
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Reagent Management System

• Practical
• Automatic loading of up to 36 Flex cartridges
  simultaneously
• Automatic disposal of used Flex
• Ideal for nightshifts and weekend duties
• Consolidation
• ca. 180 methods onboard concurrently
• Reduce sample splitting and handling
• Productivity
• Automatic reagent hydration
• Dedicated hydration station optimize
  processing efficiency

Enhanced Productivity
RMS Module
"No Reagent Prep Required By The Operator"
Dual Dimension RxL Max configuration
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The Flex Concept
"No Reagent Prep Required By The Operator"
Dual Dimension RxL Max configuration
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Lynx Option 1 Methods( gt 100 )
1 Open Channel application 2 Automated 3 Under
Development
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Lynx Option 2 Methods( gt 190 )
1 Open Channel application
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Chemistry Samples Matrix
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Alert Screens
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Alert Functions
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STAT Alert
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Sample Alert

• Focus on abnormal samples
• Auto-dilute
• Panic
• Reflex testing
• Sample being rerun for process error
• 1 button access to test results

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Supplies Alert

• Early warning for low Flex reagent
• User programmable trigger values
• Complements Systems Needs function

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QC Alert

• Individual test result flagging for out-of-range
  QC test
• Active Alert until mitigated or corrected
• Easy EDIT/Rerun

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Calibration Alert

• Early warning for expiring calibration
• User selectable intervals for alert
• Only flags on-board lots
• 1 button access to calibration set-up screens

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Sample Quality Management

• HIL Hemolysis, Icterus, Lipemia
• No reagents used water only
• 1 cuvette
• 20 uL of sample
• Customer Definable
• Intelligent sample-specific ordering
• Individual test result flagging
• 4 modes of operation
• OFF
• ON
• Auto ON
• Manual request

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HIL Configuration
Intelligent sample-specific ordering Individual
test result flagging

• Customer-defined indices alert values
• 4 modes of operation
• OFF
• ON
• Manual
• Auto-ON
• Results sent to LIS
• No impact to STAT TAT

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Automated Serum Indices

• Can be customized for selective tests
• Index levels 1 to 6
• Index 1 No interference
• Measurement filters
• H 405/700 nm
• I 452/700 nm
• L 700 nm
• No reagent
• Single cuvette 3 tests
• Results gt Indices are flagged
• Includes open channel tests

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Post Analytical Capabilities

• Quick release of the primary tube
• Output sort for additional testing
• By method
• By instrument type
• User definable racks and lanes
• Sample mapping for easy storage and retrieval

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The Dimension Lynx System

• Increase in throughput by combining integrated
  platforms

• Reduction in labor requirements

• Rapid, consistent turn-around-times

• Higher degree of quality reduced errors

• Improvement in lab safety

• Compact footprint efficient utilization of space

• Scaleable open architecture for future needs

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Dade Behring Dimension Lynx System.
Entry Level Automation.
Without the Complexity.