Overweight, Obesity, and Mortality: NIH-AARP Study

1
Overweight, Obesity, and Mortality NIH-AARP Study

• 527,265 (313,047 men and 214,218 women) 50 to 71
  years old at time of enrollment
• Maximum follow up of 10 years
• 61,317 deaths (42,173 men and 19,144 women)
• 186,000 men and women had never smoked, were
  middle-aged, and did not have coronary artery
  disease
• 20 to 40 higher risk of death in overweight
  healthy middle-aged individuals who had never
  smoked
• 2 to 3 times greater risk of death in healthy
  obese middle-aged individuals who had never smoked

Adams KF et al. N Engl J Med 2006355763-778.
2
The Effect of BMI on Outcomes in Men NIH-AARP
Study
3.0 2.5 2.0 1.5 1.0 0
3.0 2.5 2.0 1.5 1.0 0
All Men (N313,047 42,173 deaths)
Men According to Age (N313,047 42,173 deaths)
50-55 yr. 56-60 yr. 61-65 yr. 66-71 yr.
Relative Risk of Death
Relative Risk of Death
20
25
30
35
40
45
0
20
25
30
35
40
45
0
Current BMI
Current BMI
3.0 2.5 2.0 1.5 1.0 0
3.0 2.5 2.0 1.5 1.0 0
Men According to Smoking Status (N302,32740,541
deaths)
Men Who Had Never Smoked (N54,925 4079 deaths)
Never smokers Former smokers Current smokers
Relative Risk of Death
Relative Risk of Death
20
25
30
35
40
45
0
20
25
30
35
40
45
0
Current BMI
BMI at 50 Years of Age
Adams KF et al. N Engl J Med 2006355763-778.
3
The Effect of BMI on Outcomes in Women NIH-AARP
Study
3.0 2.5 2.0 1.5 1.0 0
3.0 2.5 2.0 1.5 1.0 0
Women According to Age (N214,218 19,144 deaths)
All Women (N214,218 19,144 deaths)
50-55 yr. 56-60 yr. 61-65 yr. 66-71 yr.
Relative Risk of Death
Relative Risk of Death
20
25
30
35
40
45
0
20
25
30
35
40
45
0
Current BMI
Current BMI
3.0 2.5 2.0 1.5 1.0 0
3.0 2.5 2.0 1.5 1.0 0
Women According to Smoking Status
(N207,88418,417 deaths)
Women Who Had Never Smoked (N56,156 2867 deaths)
Never smokers Former smokers Current smokers
Relative Risk of Death
Relative Risk of Death
20
25
30
35
40
45
0
20
25
30
35
40
45
0
Current BMI
BMI at 50 Years of Age
Adams KF et al. N Engl J Med 2006355763-778.