Division of Genetic and Reproductive Toxicology

1
Division of Genetic and Reproductive Toxicology

• Staff
• Research Focus Areas
• Senior Investigators
• Framework for Research

2
DGRT Staff

• 31.8 FTE Government positions
• 14 Research Scientists
• 3 Staff Fellows
• 12.8 Support Scientists
• 2 Administrative
• 6 ORISE Post Docs
• 1 ORISE Pre Doc

3
DGRT Research Focus Areas
Diet and Nutrition
Genetic Toxicology
Reproductive/ Developmental Toxicology
Genomics Proteomics
4
Senior Investigators--Genetic Toxicology
In vivo Bob Heflich Ben Aidoo Tao
Chen Vasily Dobrovolsky Jim Fuscoe Magomed
Khaidakov Manju Manjanatha Page
McKinzie Suzanne Morris Barbara
Parsons Carrie Valentine
In vitro Suzanne Morris Tao Chen Bruce
Hass TBN
Staff Fellow Post Doc
5
Senior Investigators--Reproductive/DevelopmentalT
oxicology
Deb Hansen Bill Branham Ming Lu Dan Sheehan
6
Senior Investigators--Diet and Nutrition
Ritchie Feuers Peter Duffy Varsha
Desai Ming Lu Ben Aidoo Deb Hansen Bob
Heflich Sachin Bendre Suzanne Morris
Post Doc Pre Doc
7
Senior Investigators--Genomics and proteomics
Jim Fuscoe Ritchie Feuers Angela Harris Varsha
Desai Suzanne Morris
Post Doc
8
Framework for DGRT Research
CDER
CBER
CVM
CFSAN
CDRH
Basic Applied Research to Improve Regulatory
Decision Making (Risk Assessment)
OWH
Chemical Specific Information
9
Framework for DGRT Research
Basic Applied Research to Improve Regulatory Decis
ion Making (Risk Assessment)
--Hazard Characterization --Dose Response
Assessment
10
Framework for DGRT Research
Hazard Characterization --Develop new
methods --Characterize/understand
assays --Interpretation of data --Modes of
action for toxicants --Rodent/human
extrapolation --Develop guidelines
11
Framework for DGRT Research
Hazard Characterization --Develop new methods
PhiX174 Gene Mutation
Keratinocyte hprt
TK/- Mouse Model
MutEx/ACB-PCR Genotypic Selection
Endocrine Knowledge
Fluorescent Markers
12
Framework for DGRT Research
Hazard Characterization --Characterize/understand
assays --Interpretation of data
In Vivo Mouse TK Assay
In Vivo lacI and hprt
Human Lymphoblastoid TK Assay
Filter Arrays
Mouse Lymphoma TK Assay
13
Framework for DGRT Research
Hazard Characterization --Modes of action for
toxicants
DNA Sequence Analysis
Folate Neural Tube Development
Chromosomal Mutations Genomic Rearrangements
Impact of Dietary Restriction on Somatic
Mutation and Physiological Parameters
Gene Expression Protein Production
14
Framework for DGRT Research
Hazard Characterization --Rodent/human
extrapolation
Response of Hepatocytes to Toxicants
Response to Dietary Restriction Nutritional
Changes
15
Framework for DGRT Research
Hazard Characterization --Develop guidelines
Mouse Lymphoma TK Assay
In Vivo Gene Mutation Assays
16
Framework for DGRT Research
Dose Response Assessment --Relevant
doses --Susceptibility/variability --Rodent/huma
n extrapolation --Cancer/noncancer --Quantitativ
e models
17
Framework for DGRT Research
Dose Response Assessment --Relevant doses
Dose Selection
Genomics/Proteomics
Biomarkers
18
Framework for DGRT Research
Dose Response Assessment --Susceptibility/variabi
lity
Fetus/Newborn/ Young Child
Diet Antioxidants Dietary Restriction Phytoestrog
ens
Repair Deficiency PMS2-Mismatch Mice
19
Framework for DGRT Research
Dose Response Assessment --Rodent/human
extrapolation
Liver Toxicity
Biomarkers
Diet and Nutrition
Genomics/Proteomics
20
Framework for DGRT Research
Dose Response Assessment --Cancer/noncancer --Qu
antitative models
Mechanistic Commonality
Genomics/Proteomics
21
Framework for DGRT Research
--Genistein --Coumestrol --Leucomalachite
Green --AZT --UV light/Phototoxicity
Chemical Specific Information
22
Cross Agency Collaboration
DBT
DGRT
DBRA
DNT
CDER
OWH
CFSAN
NIEHS
ACADEMIA
EPA
NTP