Pyruvate

1

CoASH
Pyruvate
E3
E1

E2
NADH
NAD


Lipoate

S
S

E3 uses FAD to oxidize lipoate to S-S producing
FADH2 NAD then oxidizes FADH2 to FAD generating
NADH
E1 decarboxylates pyruvate and transfers
remaining ethanol to TPP
E2 transfers ethanol to CoA and lipoate reduces
the alcohol to a keto group