Pioneering Mass Spectrometry Technology

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Pioneering Mass Spectrometry Technology
One for All" Mass Spectrometer detect masses
from the size of an atom to cancer cells
Dual-polarity MALDI-TOF Mass Spectrometer
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Dr. Yi-Sheng Wang and Dr. Chung-Hsuan Chen in the
Division of Key Technology Development in
Genomics Research Center (GRC) recently developed
a novel Dual-Polarity Matrix-assisted Laser
Desorption/Ionization Mass Spectrometer which can
be used to simultaneously measure both positive
and negative ions from a biomedical sample. Since
some biomolecules tend to form positive ions and
some to become negative ions, all present
commercial mass spectrometer cannot get a
complete biomolecular imaging. With this
invention, imaging of many more different
biomolecules can possibly be achieved. This work
has been published in a highly regarded journal.
(S. T. Tsai, C. W. Chen, L. C.L. Huang, M. C.
Huang, C. H. Chen and Y. S. Wang, Simultaneous
mass analysis of positive and negative ions using
a dual-polarity time-of-flight mass
spectrometer, Anal. Chem. 78, 7729-7734 (2006))
The patent application is in process.
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Dr. Chung-Hsuan Chen at GRC, Dr. Huan-Chang Chang
at Institute of Atomic and Molecular Sciences
(IAMS) and their research team recently invented
a Charge-Monitoring Laser-induced Acoustic
Desorption Mass Spectrometer (LIAD-MS). This mass
spectrometer can be used to rapidly measure the
masses and mass distribution of cells and
microparticles. This instrument can measure
several thousand cells within one hour. It can be
further improved to measure mass range from atom
to cell in the future. This work has been
published in one of the top scientific journals.
(P. Peng, H. C. Lin, M. L. Chu, L.T. Yu, H. C.
Chang, and C. H. Chen Charge Monitoring
Laser-induced Acoustic Mass Spectrometry for
Microparticle Mass Distribution Measurement
Angew. Chem. Inter. 46, 3865-3869 (2007)) Patent
application is also in process.