Kost, krft og helbred internationale perspektiver funding

1
Kost, kræft og helbred- internationale
perspektiver- funding

• Kim Overvad
• Department of Clinical Epidemiology
• Aarhus University Hospital
• Denmark

2
European Prospective Investigation into Cancer
and Nutrition

• Kim Overvad
• Department of Clinical Epidemiology
• Aarhus University Hospital
• Denmark

3
EPIC collaborating centres
Tromsø
Umeaa

Malmoe
Aarhus
Copenhagen
Utrecht
Cambridge
Potsdam
Bilthoven
Oxford
Heidelberg
Paris
I.A.R.C.
Milan
Lyon
Turin
Oviedo
Florence
San Sebastian
PAMPLONA
Naples
Barcelona
Athens
Murcia
Ragusa
Granada
4
Subject recruitment in the EPIC study
End of subject recruitment
Subjects included
Blood
Questionnaire
1996
40 000
41 500
Spain
1998
48 000
48 000
Italy
1998
43 000
88 000
UK
1998
36 000
40 000
Netherlands
1993
21 000
73 000
France
1998
51 000
53 000
Germany
1999
29 000
29 000
Greece
1996
54 000
54 000
Sweden
1997 1998
56 000 9 000
57 000 37 000
Denmark Norway
386 000
520 000
Total 10 countries
5
EPIC data on diet

• Two dietary measurements
• Dietary questionnaire on usual diet from all
  520,000 subjects
• Very detailed, 150 to 300 foods per
  questionnaire
• To relate diet to cancer risk
• One day diet from a 7 sample of subjects
  (38,000)
• Computerised, 3000 foods and 700 recipes per
  country
• To calibrate dietary measurements between
  countries

6
Total fruit consumption (grams/day) in EPIC
adjusted for age, season and day of the week
Men
7
Vegetables
Denmark Men Women
Fruits
Fruit and Vegetable Juices
250
Potatoes
Alcohol
200
Soft drinks
Legumes
150
Coffee
100
Cereals and Cereal Products
50
Tea
Cakes
0
Sauces
Sugar and Confectionery
Fish and Shellfish
Vegetable oils
Processed Meat
Margarines
Fresh Meat
et al., in press
Butter
Dairy Products
Milk
8
EPIC data related to lifestyle and personal
history

• From questionnaire
• Tobacco
• Alcohol
• Reproductive history
• Occupation
• Illnesses
• Physical activity
• Socio-economic status

• Measurements
• Height
• Weight
• Waist circumference
• Hip circumference
• Sitting height

9
EPIC blood collection and storage

• 30 ml blood 20 ml citrated 10 ml dry
• preparation of 24 aliquotes of 450 ?l
• plasma 12 (red straws)
• serum 8 (yellow straws)
• buffy coat 4 (blue straws)
• red blood cells 4 (green straws)
• Total 24 x 380.000 subjects 9.16 million
  aliquotes

10
Internationale samarbejdsrelationer- EU

• Kræftsygdomme
• EPIC-Coordination Action
• Genom scanning (ansøgning)
• Andre forskningsområder
• Interact, diabetes
• HEPADIP, fedme/lever
• Panacea, kropsbygning
• Idames, kostundersøgelsesmetode
• EPIC-Elderly, kvalitetsleveår
• Diogenes, kropsbygning

11
Internationale samarbejdsrelationer - andre

• Framingham studierne
• Atrieflimren NIH (ansøgning)
• Harvard School of Public Health
• Diabetes, iskæmisk hjertesygdom Merck
  (forhandling)
• EPIC-Heart
• Iskæmisk hjertesygdom Wellcome Trust
  (ansøgning)
• Sysdiet
• Kost og systems biology Nordiske Forskningsråd
• DanORC
• Fedt, protein og kropsbygning Strategiske
  Forskningsråd

12
Satsningsområder

• Kost, livsstil, genetisk følsomhed og helbred
• Kræftsygdomme
• Kræftens Bekæmpelse
• Metabole syndrom
• Risikofaktorer for udvikling af det metabole
  syndrom
• Kliniske følger af det metabole syndrom
• Systems biology
• Genom scanning
• Gen expression
• Omics teknologi

13
Strategi

• Kræftsygdomme
• Kræftens Bekæmpelse initierer
• Andre forskningsområder
• Opbygge erfaring og ekspertise
• Partnere
• Work Package ansvarlige
• Research Line ansvarlige
• Koordinatorer