BIOE 498 Senior Design

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BIOE 498Senior Design

• Fall 2009
• Orientation

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Contact Information

• Dr. Jenny Amos
• 3113 DCL (I moved!)
• jamos_at_illinois.edu
• 217-333-4214

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My Background

• BS Chemical Engineering and Computer Science
• PhD Chemical Engineering area focused in Tissue
  Engineering
• Dissertation A Mechanotransduction Study of
  Chondrogenesis Using a Novel Tubular Scaffold
• Areas of research/experience
• Developmental biology
• Histology
• Tissue engineering (scaffold bioreactor design)
• Hydrogels/Shape memory polymers
• AFM
• Six Sigma
• Tribology
• Gene arrays
• Fluid dynamics
• Rheology
• Computer programming (C, Perl, VB, Java)

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My Philosophy for This Course

• Attendance is not mandatory, but some lectures
  will be, you will be warned about those and you
  must do your best to attend those lectures
• However, if your grade is slipping, you might
  want to attend since I will likely curve based on
  attendance
• I know you do group work, I did too as a student,
  but turn in your own work
• I have a practically photographic memory and Im
  good at spotting similarities
• Some people like laptops in class, I find them
  annoying and distracting
• I sat in the back of Biomaterials often, I saw
  all of the Gmail, crosswords, Bejeweled, etc.
• If youre bringing it to class, youd better be
  taking notes

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My Philosophy for This Course

• Keep answers concise on homeworks, I dont want a
  novel
• Writing more only invites an opportunity to
  contradict yourself
• Please type assignments unless your handwriting
  is really neat
• Please dont talk during class unless youre
  talking to me or class is open for discussion
• Ill stop talking and everyone will stare at
  younot fun
• I end my lectures when they end, I see no need to
  torture you for the additional 10-20 minutes
  because thats how long we have

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My Philosophy for This Course

• You are all seniors in BIOE, congrats you made
  it!
• That means that you have earned a certain degree
  of respect but you must still respect your
  professors
• Its okay to eat in class but keep it small,
  simple, and quiet
• Its going to be hard to fail this course so
  please dont try )
• Id like to give out all As and Bs, maybe even
  all As

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Failure is not an option

• Grade school failure is not allowed
• High school learn basic tools
• Freshman-Junior years advanced tools and how
  to use them
• If you work hard, success is likely
• Senior Design use the tools!
• Students work in Teams, and solve a problem for a
  Client, guided by the Instructors
• Grad school?
• MS thesis solve a (hard) problem
• You are the Team
• PhD thesis identify a hard problem and solve it
• You are the Client and the Team
• The real world
• Recognize that there is a problem, and proceed
• You are Instructor, Client, and Team!

You Are Here
Failure is not an option its already bundled
into the system anon, Microsoft,
1998
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Best Efforts - Mine

• This is BIOE coming from 498 to 435 this year
• Special Topics work in progress, permanent
  course number tested and approved
• Not everything has been tried, tested, refined
• There may be some bumpy bits
• Material is subject to change
• We will stick to the schedule as best we can but
  if Im going to fast or too slow let me know
  and well adjust
• A simple email or chat after class will suffice ?

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Website, Textbook

• http//www.bioen.illinois.edu/courses/BIOE498/SMM/
  bioe498.html
• Will be updated throughout the year
• Check often
• Design of Biomedical Devices and Systems Paul H.
  King and Richard C. Fries
• Homework assignments will come from this book. I
  will not assign reading but it is suggested

Yes, its a pink book, sorry!
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What to expect

• Fall semester may start easy
• The lecture material is not rocket science
• The assignments are not killers
• The tools you will learn are important so just
  play along
• Late Fall will be bad
• Your Team must talk to and negotiate withyour
  Client, on his/her schedule
• You must be prepared! Plans, Budgets, whatever!
• Spring semester will be worse!
• Presentations, status meetings, reviews, reports
• More time talking to your Client
• Time in the lab researching, developing
• Time finding materials, supplies
• Time spent finding/working-with machine shops
• Time lost on disaster recovery

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Time is Money

• You can not afford to be idle, ever!
• If you are waiting on item A, you should be
  working on item B
• Fall, Winter and Spring Breaks, arent
• They can be part relaxing and part thinking
• You should come back from Winter Breakwith
  napkins, envelope-backs, scraps of paper,covered
  with concept ideas
• Writing in your Design Notebook is better ?
• If you wait, you will fail

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Course Outline (planned)

• Fall 2009
• Orientation, basics
• Lectures
• Guest Lectures (Patents, FDA, bioengineering in
  the real world)
• Client Presentations
• Project Discussions, in class
• Six Sigma
• Fall Break
• Winter Break

• Spring 2010
• First Presentation (teams)
• Status meetings (no lectures)
• Design Reviews (no lecture)
• Presentations (teams), QA
• Report (student reviewers)
• Status meetings (no lectures)
• Spring Break
• Design Notebook Review
• Status meetings (no lectures)
• Final Presentations (tba, teams)
• Final Report Notebook due

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When, where (planned)

• Lectures (including Guest), and Client
  presentations (Fall)
• Tuesdays, Thursdays 5pm 620pm
• 2320 DCL
• Project Discussion, in class (Nov)
• Same as Lecture
• Planning meetings (Fall) and Status meetings
  (Spring)
• Half hour per team
• Additional time available, on request
• To be scheduled at a fixed time each week
• 3113 DCL (my office)
• First Presentation (January)
• Same as Lecture
• Design Reviews (Spring)
• Same as Status Meeting, twice (details later)
• Final Presentation (May)
• To be determined (when, where)

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Lecture Subjects (planned not necessarily in
order)

• The Design Process
• The Design Problem
• Concept Design
• Intellectual property, patents
• Materials, Manufacturing
• Configuration Design, DFM
• Parametric Design
• Prototyping, Testing
• FMEA, DFX
• Liability, risk, safety
• Human Factors, ergonomics
• Quality/Six Sigma
• Ethics
• Project Planning, budgets
• Design Reviews Value Engineering

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Six Sigma

• I am a Six Sigma green belt and you will be
  trained in Six Sigma and receive a green belt
  certificate after this course
• Put this on your resumes!
• We will cover important Six Sigma concepts and do
  an assignment in the fall to solidify concepts
  and then a small project related to your design
  project in the spring
• If you are already a Six Sigma green belt, then
  please meet with me, maybe we can incorporate
  something you did into the lectures as well

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What are Projects?

• Problem research
• Meetings with a faculty sponsor (Client)
• Resource search
• Project planning and execution
• Analytical thinking
• Quantitative decision making
• Teamwork
• Creativity, and mindless labor!
• Documented in a Design Notebook
• Producing a new, Bioengineering-relevant
  Prototype
• By the end of Spring 2009

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Projects 2007-2008

• A Robotic Leg Test Fixture to Simulate Normal and
  Abnormal Gait Patterns
• The iFishbot A Robot for the Simulation of
  Active Sensing Organisms
• Applied Breath Technologies' SLEBA 1
• pH and pH2O2 from exhaled breath
• The Birth of the Cali-BRAIN-te
• MRI phantom
• FTIR Spectroscopic Needle Probe for in situ
  Pathology
• Phenotype Database Merger
• Multiple Needle Biopsy Device for Tissue Analysis
  of Angiogenesis
• pathwayfindr customizing cellular signaling
  pathways

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Projects 2008-2009

• The 21st Century Personal Emergency Response
  System
• Optical Coherence Tomography (OCT) in a Handheld
  Probe for Breast Cancer Imaging
• Bacteria Film Tracking Program
• Endoscopic OCT Needle Probe
• Biological Network Inference Suite for Clustering
  Gene Arrays
• Intra-operative Leg Length Measuring System
• Acoustical Tweezers for Moving Micro and Nano
  Objects

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Project Rules (for Clients)

• Product, not research or service
• New
• Clients talk to Teams, Instructors talk to
  Students and Teams
• Clients provide lab resources but also there are
• Sr Design Project lab 3116 DCL
• Fabrication Lab basement DCL, TBA
• Up to 500 per project, from Bioengineering
  Department
• Clients are free to provide more ?
• The fundamental deliverable Prototype
• Prototype belongs to Client
• Intellectual property Client and Team

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Actors and Communications
Team
Client (Sponsor)
Student(s)
Instructor and support
No!
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Money (planned)

• It is likely that each Team will purchase
• Parts (chemical, mechanical, electrical)
• Services (machine shop time)(note pure software
  projects not so much)
• The Bioengineering Department has finite finances
  available, (planned) 500 per project
• The amount of money available for your Team will
  be determined by the needs of all Teams
• Software projects are expected to cost 0
• All purchases will be coordinated through the
  Bioengineering Department
• Elizabeth Stovall her rules are Law!
• Plan to fill out Purchase Forms, etc.
• Details later

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Memorandum of Understanding (MOU)

• contract, Client Team
• Template will be provided by the Instructors
• Negotiated
• Details will be determined by Client and Team
• Instructors can mediate
• Defines who, what, when
• Calls for Best Effort
• Stuff happens
• Will be amended, throughout the design year
• Refined, as the design matures
• Adjusted, in response to surprises
• But the bottom line is that you must work with
  the Client!
• The (pre-amendment) MOU must be signed (by all
  parties) by Finals Week before Winter Break

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Project-related Events (planned)

• In-class Client presentations (mid Oct)
• Identify projects
• Team assignments (early Nov)
• Followed by Team-Client meetings
• In-class discussions of projects (before Fall
  break)
• Project planning meetings after break
• signed MOU (before Winter break)
• First Presentation (January)
• To the class introduction, by the Team
• Website Planning and start
• Weekly status reports emailed to Instructors
  (cc to Client)
• Weekly (Bi-weekly?) status meetings
• Team Instructors, 50 minutes per Team, to be
  arranged
• Design Reviews (before Spring Break)
• Team Reviewers ( anyone interested), 1 hour
  per Team, times 2
• Design Notebook Review
• By Instructors, during Spring Break
• Final Presentation and Website (before Spring
  finals)
• To the public outcomes

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Design Reviews (planned)

• Late Feb (S6), Instructors will
• provide a charge document setting the rules and
  responsibilities of all parties
• for each Team, select 3 other students (not on
  Team, not on same Teams) to serve as Reviewers
• Then, Teams will email review material (URLs) to
  their Reviewers
• Early March (S7)
• Each Team will present their project, design
  choices (what, and why), and current status 15
  minutes
• Reviewers will review, ask questions 35 minutes
  
• After, Reviewers write/email a report
• Findings (statements of fact)
• Recommendations (opinions)
• Following week (S8)
• Roles reverse Reviewers present their Report
  15 minutes
• Teams ask questions, or provide rebuttal 35
  minutes
• To be conducted during the Teams regularly
  scheduled Status meeting
• Reviewer selection/assignment may be tricky, to
  fit schedule
• Modeled on Department of Energy (and others)
  critical decision review process

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Final Presentation

• To be defined, Spring 2009
• But this is what you can look forward to
  (planned)
• 15 minutes describing your project to the public
• Problem, plan, outcome
• Presented by the Team
• to BIO 498 students, Clients, interested faculty,
  others
• esp. Juniors with fears about next fall
• Followed by 5 minutes of QA
• Intermission snacks and drinks (non-EtOH)
• And after all presentations (planned)
• 30 minutes of vendor fair
• Your Team behind a table, showcasing your
  prototype
• You will need to advertise (poster, brochures
  banner, etc.)

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Final Report

• To be defined, Spring 2009
• But this is what you can look forward to
  (planned)
• problem, mission, and plan
• contract
• schedule, budget
• design process documentation
• Due diligence
• what was considered, planned
• as-built documentation
• what was done
• plan/project critique
• 20-20 hindsight
• what should have happened, what did happen, why
• Reviewers recommendations, revisited
• Followed/rejected, and why

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Design Notebook

• Each student must keep a Design Notebook
• Typically paper
• Bound, or 3-ring
• Can be electronic
• If so, must be printed for Review (Spring Break)
• To contain dated copies of all ideas,
  discoveries, plans, laments
• Organized in sections, for Review (Spring Break,
  and Final)
• Hence 3-ring may be wiser
• To contain a journal of email exchanges
• You can filter out the noise, but too much is
  better than missing something
• To contain the dates, names of participants, and
  minutes/notes from all official meetings
• Planning meeting, Client-Team meetings, Design
  Review, other
• Start now!

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Example Design Website

• From U Rochester

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Example Design Website

• From Penn State

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Course Rules

• Cell phones off, or equivalent
• If I can hear it, you will suffer!
• Assignments, Reports are due on time
• Meetings begin/end on time
• Most Instructor meetings will be xx00 to xx30
• Most things are negotiable
• But only before, not after!

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Grading

• Fall 2008
• Assignments (written)
• 60
• Client Assessment
• 30
• Other /- 10
• in-class participation
• Web content provided
• Other contribution to the course10
• Being here 0
• Making my life miserable(without a good
  reason) -10

• Spring 2009
• Presentations
• 30
• Final Report Notebook
• 30
• Client assessment
• 20
• Weekly Meetings/Weekly reports
• 20

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What is a Good Reason?

• Each Team will do something different
• Each Student has a different (perhaps valid ?)
  perspective
• I could be wrong
• Therefore, if you disagree with something,lets
  talk about it
• However, after the debate, you must comply
• My obligation is to be flexible, reasonable
• Your obligation is to accept it

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Outstanding, Adequate, and Failed

• Every Team will do something different
• Projects are hopefully as balanced as is fair but
  are very different
• The fundamental grade-scale will be
• Work hard, work smart Outstanding (A)
• Do the work, and be very lucky Adequate (B)
• Dont count on being lucky
• Anything less Failure

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Assignments (planned)

• Design warm-up
• Concept Design
• Configuration Design
• Six Sigma Project
• FMEA, Liability
• Contract
• Purpose
• Problem statement
• Mission statement
• Project Plan
• Tasks
• Milestones
• Budget
• Obligations resources, deliverables
• Rules
• And in the Spring, weekly Status Reports (details
  later)

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Assignments, Reports

• Typed
• Handwritten will lose points
• E.g. Outstanding gt Adequate, Adequate gt
  Failed
• Paper and/or electronic documents
• Word, Excel, Powerpoint, website designIf you
  dont know these, learn now!Or plan to hire
  someone, at your expense
• Will often include figures and drawings
• And tables

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Figures, Drawings, etc.

• You will need to include artwork in your
  assignments and reports
• AutoCAD, ProE
• PowerPoint/Word
• Cutpaste
• PrintScreen, crop, scale
• annotate
• Start now!
• Hand-drawn art will lose points

annotation
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Handing in Assignments, Reports

• Paper, or email
• Special cases will be specifiedHowever...
• Do not email attached documents larger than 500
  KB !
• Email was not intended for file transfer
• It costs a lot more than you might imagine!
• Post the document(s) to a website, and email the
  URL Use your Wiki or NetFiles

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Posting Documents

• Everyone has a Netfiles accountwww.cites.uiuc.ed
  u/netfiles/
• Documents can be public
• Documents can be read-restricted to specific
  Net-IDs
• Documents can be read-restricted by guest ticket
  (which you can email)
• Some students may work in research groups that
  have web pages, see if you can use them
• Some may have ISP/other resources
• Find out now. Ask for help if you need.

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Design Notebook exception

• Your Design Notebook may be
• Handwritten, hand sketched
• With scraps of paper taped to pages
• and napkins, laminated in plastic
• Electronic
• With cutpaste figures from the web
• And scanned/photographed images
• You Design Notebook will be
• Reviewed by the instructor during Spring Break
• Due for final review/grade, along with your Final
  Report
• Returned to you after grading
• Final Report will not be returned, but
  grade/comments will be available
• I have examples in my office, if you are curious

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Ethics and Attribution

• Assignments, Notebook Students
• Presentations, Reports Teams
• Team efforts must show all names
• If you have a team member not contributing tell
  me ASAP so that you arent penalized
• Students may collaborate
• Assignments must show your name
• To receive grade/credit
• and the names of your collaborators
• Anything less is cheating

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Engineering Design

• Is not just finding one solution to the problem
• It is not art, sprung full-grown from the brow of
  the creator
• It is a series of decision-making processesto
  determine the form of the solutiongiven the
  functions required by the Client

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Why not just find one solution?

• Self satisfaction in a job well done?
• Yeah, right.
• Profit
• 3. Never spend more for an acquisition than you
  have to.
• Rules of Acquisition.
• And next team can do it better
• They will profit from your RD you will not!
• Value engineering

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Value Engineering

• Public Law 104-106 Each executive agency shall
  establish and maintain cost-effective value
  engineering procedures and processes."
• http//oecm.energy.gov/Portals/2/PL104_106.pdf
• OFPP Act, section 432 value engineering
  meansan analysis of the functions of a
  program, project, system, product, item of
  equipment, building, facility, service, or supply
  of an executive agency, performed by qualified
  agency or contractor personnel, directed at
  improving performance, reliability, quality,
  safety, and life cycle costs
• The Office of Federal Procurement Policy
• Value function/cost
• Maximize function, minimize cost
• If you do any engineering for/with the U.S.
  Government, you may be required to perform a
  Value Engineering analysis.

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You Will DemonstrateDue Diligence

• You can use
• Concept DesignConfiguration DesignSix
  SigmaFMEA, Liability assessmentValue
  Engineering Analysis
• Your Design Reviewers will be required to
  determine the verb-noun base function(s) of
  your project. Details later.
• Or you can do something else
• Equally compelling
• However, your final report will demonstratethat
  you have evaluated alternatives, and havea sound
  engineering basis for your solution.

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Questions?
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By Next Time

• Identify your website for posting assignments
• Netfiles, other
• Email to me a URL of a document on your site
• To test the concept
• If you have difficulties, email to mea request
  for help