Research Opportunities

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Research Opportunities Summer 2004 and Academic
Year 2004-2005 Dr. James Vyvyan Office
CB341 E-mail vyvyan_at_chem.wwu.edu Web Page
http//lightning.chem.wwu.edu/dept/facstaff/ vyvy
an/vyvyan.shtml See Dr. Vyvyan for an application
form Application deadline is April 12,
2004 Projects focus on the synthesis of the
heliannuols (1-12) and related compounds.Applican
ts should have completed the organic chemistry
lecture series (Chem 351-353) and at least one
quarter of organic chemistry laboratory (Chem
354). Summer positions are full-time for 10 weeks
and pay 350 per week. It is anticipated that 1
or 2 positions will be open for summer 2004,
depending on availability of grant
funds. Academic year positions earn academic
credit (Chem 301, 401). It is anticipated that
2 or 3 positions will be open starting fall
2004.
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Chem Seminar This Week
Friday Mar 12 Prof. A. Patricia Campbell
University of Washington (Medicinal
Chemistry) "NMR Guided Design of a Breast Cancer
Vaccine"
315 pm, CB 285 Refreshments at 300 pm in CB 260
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Figure 26-11 Degradation of amino acids to one of
seven common metabolic intermediates.
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Figure 26-12 The pathways converting alanine,
cysteine, glycine, serine, and threonine to
pyruvate.
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Figure 26-26 The pathway of phenylalanine
degradation.
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Figure 26-26 The pathway of phenylalanine
degradation.
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Figure 26-26 The pathway of phenylalanine
degradation.
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Figure 26-27 The pteridine ring, the nucleus of
biopterin and folate.
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Figure 26-28 Formation, utilization, and
regeneration of 5,6,7,8- tetrahydrobiopterin
(BH4) in the phenylalanine hydroxylase
reaction.
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Figure 26-30 Proposed mechanism of the NIH shift
in the phenylalanine hydroxylase reaction.
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Figure 26-31 The NIH shift in the
p-hydroxy- phenyl- pyruvate dioxygenase
reaction.
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Homogentisate
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Figure 26-47 Tetrahydrofolate (THF).
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Figure 26-48 The two-stage reduction of folate to
THF.
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Table 26-1 Oxidation Levels of C1 Groups Carried
by THF.
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Figure 26-49 Interconversion of the C1 units
carried by THF.
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Figure 26-50 The biosynthetic fates of the C1
units in the THF pool.
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Figure 26-51 The sequence of reactions
catalyzed by glutamate synthase.
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Table 26-2 Essential and Nonessential Amino Acids
in Humans.
We cant make these!
We can make these!
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Figure 26-54 The syntheses of alanine,
aspartate, glutamate, asparagine, and glutamine.
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Figure 26-55a X-Ray structure of S. typhimurium
glutamine synthetase. (a) View down the 6-fold
axis of symmetry showing only the six subunits of
the upper ring in alternating blue and green.
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Figure 26-56 The regulation of bacterial
glutamine synthetase.
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Figure 26-66 Photograph showing the root nodules
of the legume birds foot trefoil.
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Figure 26-67 X-Ray structure of the A. vinelandii
nitrogenase in complex with ADP AlF4 -.
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Figure 26-69 The flow of electrons in the
nitrogenase-catalyzed reduction of N2.
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Figure 26-59a Cysteine biosynthesis. (a) The
synthesis of cysteine from serine in plants and
microorganisms.
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Figure 26-59b Cysteine biosynthesis. (b) The
8-electron reduction of sulfate to sulfide in E.
coli.
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Chapter 27 Integration of Metabolism
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Figure 27-1 The major energy metabolism
pathways.
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Figure 27-2 The metabolic interrelationships
among brain, adipose tissue, muscle, liver, and
kidney.
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Table 27-1 Fuel Reserves for a Normal 70-kg Man.
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Figure 27-5 Hormones that control the appetite.
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Chapter 28 Nucleotide Metabolism
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Figure 28-1 The biosynthetic origins of purine
ring atoms.
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Figure 28-2 The metabolic pathway for the de novo
biosynthesis of IMP.
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Figure 28-4 IMP is converted to AMP or GMP in
separate two-reaction pathways.
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Figure 28-5 Control network for the purine
biosynthesis pathway.
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Figure 28-6 The biosynthetic origins of
pyrimidine ring atoms.
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Figure 28-7 Metabolic pathway for the de novo
synthesis of UMP.
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Figure 28-8 Reactions catalyzed by eukaryotic
dihydroorotate dehydrogenase.
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Figure 28-10 Synthesis of CTP from UTP.
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Figure 28-11 Regulation of pyrimidine
biosynthesis. The control networks are shown
for (a) E. coli and (b) animals.
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Figure 28-12a Class I ribonucleotide reductase
from E. coli. (a) A schematic diagram of its
quaternary structure.
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Figure 28-16 Electron-transfer pathway for
nucleoside diphosphate (NDP) reduction.
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Figure 28-21 Regeneration of N5,N10-
methylene- tetrahydrofolate.
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Figure 28-23 Major pathways of purine
catabolism in animals.
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Figure 28-28 Degradation of uric acid to ammonia.
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Figure 28-29 The Gout, a cartoon by James Gilroy
(1799).
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