Hydrogels for Drug Delivery Applications and the pH Scale

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Hydrogels for Drug Delivery Applications and the
pH Scale

• Amalia C. Cuadra
• Advisor Dr. Anthony Lowman
• School Military Academy at Elverson

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PA Standards
Explain and apply concepts about the structure
and properties of matter

• 3.4.12 Characterize and identify important
  classes of compounds (e.g., acids, bases, salts).
  
• 3.4.10 Explain the formation of compounds and
  their resulting properties using bonding theories
  (ionic, covalent and hydrogen)
• 3.4.10 Describe various types of chemical
  reactions by applying the laws of conservation of
  mass and energy
• 3.4.10 Apply knowledge of mixtures

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Unit Objectives

• Students Will be Able to (SWBAT)
• SWBAT compare and contrast the differences
  between acids and bases
• SWBAT describe the properties of acids and bases
  at a macroscopic and molecular level
• SWBAT define Brønsted-Lowry acids and bases
• SWBAT convert between pH and H
• SWBAT determine conjugate acids and bases
• SWBAT apply their understanding of acids and
  bases to a research-based real world application

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Hydrogels
What are Hydrogels?

• hydrophilic compound
• water insoluble polymer
• water absorbent (up to 99 of
• weight can be water)
• promising applications for
• biomaterials and drug delivery

P-EG
Uses of Hydrogels
pH Sensitive Hydrogels

• diapers, they absorb!
• contact lenses, silicone based
• tissue engineering
• drug delivery applications

• able to sense environment and
• modify absorption properties
• can be used for oral insulin
• delivery

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pH, the Digestive System and Insulin
Insulin

• anabolic polypetide hormone (protein)
• regulates carbohydrate metabolism
• signals the liver for glucose release
• fail to produce ? Type I Diabetes
• insulin resistance ? Type II ()

place in hydrogel network
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pH, the Digestive System and Insulin
Average pH2
Average pH7
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The pH Scale
Interactive Assignment

• Objective
• SWBAT to convert H
• and pH
• Plan
• demonstrate the use of
• simulation with sulfuric acid
• create a diagram with pH and
• molar concentration
• Assignment
• students will plot pH for
• hydrochloric acid (found in
• stomach) while varying molar
• concentrations

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Questions Comments?