POTENTIALS OF

1
POTENTIALS OF AYURVEDA IN
LIFE STYLE DISEASES A FOCUS ON RESEARCH AND
DEVELOPMENT
Dr. G.S. LAVEKAR
DIRECTOR CCRAS
2

OBJECTIVES OF AYURVEDA

• Ayurveda is one of the greatest contributions of
  our country to the mankind. It has unique and
  distinctive holistic approach to the health and
  illness.
• Ayurveda with its rich potentials is serving the
  humanity.
• The objectives of Ayurveda are
• Health Promotive
• Preventive
• Curative and
• Rehabilitative

3

• HOLISTIC APPROACH
• Ayurveda is based on the laws of Nature. The
  theory of Loka-Purusa-Samya ,Brahmand-pinda
  (macrocosm-microcosom (Continum) is the most
  important principle of Ayurveda.
• The individual human being is the miniature
  replica of universe.
• The individual (Purusa) and the universe (loka)
  remain in constant interaction with each other
  and also derive and draw materials from each
  other in order to maintain their normalcy and
  homeostasis.

4

• SOURCE OF DRUGS
• Ayurveda considers all the substances in the
  world as drugs if used appropriately according to
  status and severity of disease as well as
  patient.-There are three main sources of drugs
  according to Ayurveda that include -Plant
  sources
• -Animal sources
• -Metals/Mineral, marine sources

5
RICH BIODIVERSITY

• India is one of the 12 mega-biodiversity
  countries harbouring two unique biodiversity
  hot-spot out of 18 hot spots in the world.
• It is rich in all the three levels of
  biodiversity i.e. species diversity genetic
  diversity ad habitat diversity.
• Under such unique and varied agroclimatic
  bio-edaphic variety of medicinal plants grow.
• Out of 17,000 flowering plants, 8000 species
  (MoEnF, AICRPE-report) are used medicinally in
  local health traditions and codified system of
  medicine.

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• The intra-specific variability of the flowering
  plants found in the country make it one of the
  highest in the world.
• In Ayurveda, Siddha and Unani systems of
  medicine about 2,000 plants are used in various
  formulation.
• There are estimated to be around 25,000 effective
  plant based formulations used in folk medicine by
  the rural communities of the country, besides
  around 10,000 designed formulations available in
  indigenous medical texts.

7
Research Areas of CCRAS

• Literary and Fundamental Research
• Drug research
• Clinical Research
• RCH Research
• Neutraceutical Research
• Cosmoceutical Research
• Bio Medical Instrumentation Research.

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• In Phase Wise Implementation of clinical
  programme projection considering------
• The strength of Ayurveda
• The Disease of NATIONAL /GLOBAL importance
• 30 diseases/conditions/areas have been
  finalized.
• The medicines have been formulated based on the
  classical reference, clinical experience and
  preliminary screening through Pilot Studies.
• Currently the developmental process of 8
  formulation is in progress and pre clinical
  Formalaties viz. standardization , safety
  profile/targeted activity evaluation have been
  completed

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CURRENT STATUS OF STANDARDIZATION AND
PRE-CLINICAL SAFETY STUDIES OF CODED DRUGS
(PROGRAMME PROJECTION 2003-04) (FIRST PHASE)
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BIOLOGICAL ACTIVITIY STUDIES
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AYUSH-LIV
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Ayush LIV
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TLC of Ayush LIV
Solvent system Chloroform Methanol 11
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AYUSH-RP
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AYUSH RP
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TLC of Ayush RP
Solvent system Butanol Acetic acid Water
632710
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Ayush QOL-2
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TLC of Ayush QOL - 2
Solvent system n-Butanol Acetic acid Water
632710
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Fig-1
INFERENCE 1. Cyclophosphamide has significantly
decreased the immobility period when compared to
control Plt0.001 2. Ayush QOL-2 has
antagonized the effect of Cyclophosphamide and
confirmed immunomodulatory effect Plt0.001
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INFERENCE I.Cyclophosphamide has significantly
decreased the immobility period when
compared to control Plt0.001 2.Ayush QOL-2 has
antagonized the effect of Cyclophosphamide and
confirmed immunomodulatory effect Plt0.001
34
Inference 1.Cyclophosphamide has significantly
decreased the neutrophils
counts Plt0.001 2. Ayush QOL-2
has antagonized the effect of Cyclophosphamide
and neutrophil count is
comparable with central group
35
AYUSH RASAYAN-B
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AYUSH RASAYAN B
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TLC of Ayush Rasayan B
Solvent system Toluene Ethyl acetate 11
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AN APPRAISAL OF SOME CLINICAL RESEARCH
CONTRIBUTIONS OF CCRAS AND OTHER INSTITUTES
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Anti anxiety effect of an Ayurvedic compound drug
a cross over trial   Type of study Double
blind study with asequential crossover design
comparing the efficacy of Ayurvedic preparation
with modern control.   Ayurvedic preparation Vs.
Diazepam and Placebo   Drug and Dosage
Ayurvedic comp. consist of Mandukaparni (Centella
asiatica), Yasti (Glycyrrhiza glabra), Jatamansi
(Nardostachys Jatamansi) in the ration of 112
suspended in Ksirabala taila. RESULTS
Psychological parameters show that Ayurvedic drug
is more effective in enhancing the perceptual
discrimination and Psychomotor performance than
the other two control drugs.    The intra group
comparisons of Ayurveda group alone indicate that
the drug is effective in controlling the somatic
and psychic anxiety.   Ref .K. Kuppurajan, C.
Seshadri, V Rajagopalan, Kanchan Srinivasan, R.
Sitaraman, Janak indurathi S Venkatraghavan
Dr. A Lakshmipathi Research Center for Ayurveda
(CCRAS) VHS Campus, Chennai  
44
Effects of a Composite Indian herbal Preparation
(CIHP) on combat effectiveness in low-intensity
conflict operations.

• Drug Dosage CIHP Vs Placebo
• CIHP is a combination of
• following
  extracts
• No. of cases56
• Shatavari (Asparagus racemosus) Root
• Ashwagandha (Withania somnifera) Root
• Vidarikand (Pueraria tuberosa) Tubers
• Konch (Mucuna pruriens) Seeds
• (Dioscorea bulbifera) Rhizomes
• (Argyria speciosa) (Whole plant)
• Pippali (Piper longum) Fruit
• Asphalt(Sphatik) extract
• Results Assessment through various tests
  indicated that CIHP helps to cope with combat
  stress and sustain mental performance in adverse
  environment.
• Source Military Medicine, Vol.164, Nov. 1999.
  
•  
• 1.     

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ANTI STRESS AGENTS
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Role of the Ayurvedic Drug Brahmi (Bacopa
monnieri) in the management of Senile Dementia.
  Drug Dosage Brahmi Vs
Placebo Brahmi in the form
of

powdered
organic extract in
doses of 1 gm. in the
administered twice a

day. Duration
5 years   Results The drug not
only arrests further
memory loss but slows the process
of subsequent
acetylcholine
reduction in person suffering
from senile dementia.
Source Pharmacopsychoecologia (1990),
3, 47-52.
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BRONCHIAL ASTHMA
TAMAKA SHWASA A CLINICAL STUDY. Drugs and
Dosage Study has been conducted in two
groups Group-A Nardeeya Lakshmi Vilas Rasa (500
mg) and Godanti Bhasma
(1 gm) thrice a day with honey as
Anupana. Group-B Swasa
Kesari Tablets. Shwasa Kesari is a compound
preparation containing
Kantakari Panchang powder and
Godanti Bhasma, both in equal ratio and converted
into tablets of
500 mg. Each, one tablet thrice a day with
luke warm water as Anupana.
  Result Both groups of drugs are quite
effective, safe and no side
effects. RefJRIMH VOLVIII,NO-3 SEP1973  
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777 OIL FOR PSORIASIS DRUG 777
OIL Wrightia tinctoria FINDINGS
The recurrence is postponed and the
intensity of the lesions is very much
minimised . Efficacy of the drug
is supported by histopathological
studies.
CCRAS RESEARCH AN OVER VIEW , 2000, Dept of
ISMH ,Govt Of.India
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Psychological disorders
Effect of Ayushman-8 in Manasa mandata
(Mental retardation) in children Study
conducted on 51 low grade mentally retarded
children Drugs Ayushman-8 Vs
PlaceboStarch Centella asiatica
Bacopa monierri Age Group 5-16
years Findings Binet-Kamat Test-Numerical
increase in mental age was greater in
drugs group p0.05ltPlt0.1. SEGUIN- Form
board Test Increase in mental age shown
was significant when compared to Placebo
group Pgt0.01 Clinical improvement. Source
JRAS Vol.XIX No.3-4(1998),pp.89-97.
Bacopa monierri
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Cardiac problems
Role of Guggulu in the management of Ischemic
Heart Disease. Drug Dosage Study conducted on
135 patients in 2 groups Control group (25) -
Placebo capsules containing
lactose powder. Treatment group (110)
Purified powder of Guggulu (Commiphora
wightii) in dose of 8 gm. per day)
Results Cardinal clinical manifestations of
disease like precordial pain and dyspnoea
relieved in most of the cases. Substantial fall
of all lipid fractions like choleserol 27,
triglycerides 36phospholipids 20 and free fatty
acids 37 has indicated the possibility of
elimination/reduction of basic lesion
arteriosclerosis. The ECG changes also indicate
the effect of drug in treatment of ischemic heart
diseases.   Source Studies on Guggulu A
monograph published by CCRAS.

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AYUSH-82 FOR DIABETES MELLITUS DRUG
AYUSH-82 Mangifera indica, Syzygium
cumini, Gymnema sylvestris, Momordia
charantia with purified Shilajit
asphaltum FINDINGS Fall in FBS, PPBS
after treatment was significant (0.001)
besides 75 good response on subjective
assessment.
53
Vijaysar (Pterocarpus marsupiam) in the treatment
of Madhumeha (Diabetes mellitus) A clinical
study Drug Dosage Vijaysar in the form of

Ghansatva was
administered in
dosage of 250 mg.
twice a day. No. of cases 35
Results The drug helps in reducing

sugar levels in urine
and blood of
NIDDM subjects
SourceJournal of Research in Indian Medicine
Yoga Homoeopathy 11(2)9-15, 1976.
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A controlled clinical trial of Guggulu and P.E.
Ext. of Guggulu in Obesity and Lipid
disorders Drugs Guggulu , P.E. Ext. of
Guggulu Vs Placebo Findings Reduction in
weight and serum
cholesterol was observed in all cases.
Significant weight reduction was
found in P.E. extract treated group 2
kg/month
when compared with Guggulu group 1
kg/month.
55
SHUNTHI GUGGULU FOR RHEUMATOID ARTHRITIS DRUG
SHUNTHI GUGGULU Zingiber officinale
Commiphora mukul FINDINGS Significant
response was observed in 72 cases. There
was marked improvement of signs and
symptoms besides significant changes in lab.
parameters like RA factor,ESR etc.
Commiphora mukul
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Double blind Randomized controlled trial of
Sallaki Vs Diclofenac in treatment of Rheumatoid
arthritis. Drug Dosage Sallaki Vs Diclofenac
sodium   Sallaki given in doses of 600 mg. 3
times in a
day. Diclofenac given in doses of 50 mg.
3 times in a
day. Duration 4 weeks   Results
Efficacy of Sallaki is comparable to that of
Diclofenac in relieving the symptoms of RA.
Sallaki is even better tolerated than Diclofenac
sodium by patients of RA who have demonstrable
predisposition for gastric intolerance with
anti-inflammatory medication. SourceSelect
research papers on evidence based drugs in
Ayurveda,CCRAS ,New Delhi
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The comparative effect of Milk fortified with
Ashwagandha, Ashwagandha and Punarnava in
children A double blind clinical study. Drug
Dosage Study conducted on 60 patients in 5
groups Group-I Powdered, purified Ashwagandha
in dose of 2 gm per day. Group-II- Ashwagandha
and Punarnava in equal quantity in dose of 2 gm
per day. Group-III Ferrous fumrate with
Lactose powder in dose of 5 mg. per day with 2
gm. of lactose. Group-IV Ferrous fumrate with
Lactose powder in dose of 30mg per day with 2
gm. of lactose. Group-V Placebo (Lactose
powder) in dose of 2 gm. per day. Duration Each
drug was given for 60 days with
100 cc of milk.   Results Ashwagandha
increases body weight, total proteins, mean
corpuscular hemoglobin and MCHC
significantly while the combination increases
Hb MCHC significantly.

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NUTRACEUTICAL RESEARCH
ANTARCTICA TEA AND ANTARCTICA LADDU

•  
•   A study on effect of certain Ayurvedic Rasayana
  food supplements drink(Rasayana Rejuvenate
  Recipe) has been conducted at Antarctic
  expeditions organized by National Centre for
  Antarctica and Ocean Research, Government of
  India
• Results are encouraging in terms of
• Immunomodulatory action
• Anti-oxidant effects
• besides improvement in physical and
  physiological parameters.

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HEPATOPROTECTIVE DRUGS
Pippali (Piper longum)   Parts form Ethanol
extract of Piper longum fruits and five different
crude fractions, petroleum ether (40-60),
solvent ether, ethyl acetate, butanol and
butanone were subjected to preliminary
qualitative clinical investigations. Activity
The ethanolic extract and all other fractions
were screened orally for hepatoprotective
activity in adult Wester rats. The ethanolic
extract and butanol fraction have shown
significant activity, lowering the serum enzymes
SGOT SGPT in rat treated with carbon
tetrachloride when compared to control and LIV-52
treated rats. Ref. Jalapure, S.S. et al, 2003
Hepatoprotective activity of the fruits of Piper
longum Linn. India Journal of Pharmaceutical
sciences, Vol.65 (4) p. 363-366 (Eng 10 ref).
60

• Katuki (Picrorhiza kurroa)
•  Parts form The decoction with different
  extracts (viz. alcoholic, petroleum ether and
  chloroform) of P. kurroa.
• Activity When administered to rats with carbon
  tetrachloride induced liver injury, showed lesser
  structural damage in the hepatic tissue, as
  compared to the control rats. The alcoholic
  extract of P. kurroa showed protective action
  against hepato-toxicity induced by carbon
  tetrachloride in rabbits as evidenced by marked
  regression of serum transaminases (SGOT and SGPT)
  and serum alkaline phosphatase levels.
• Reference Pandey, V.N. and Chaturvedi, G.N.
  1968 Effect of alcoholic extract of Kutaki
  (Picrorhiza kurroa) on experimentally nduced
  abnormalities in the liver. Indian J. Res.
  Indian Med. 3 (1), 25.

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Rohitaka (Tecoma undulata)   Parts
form Alcoholic extract of Rohitaka dissolved in
propylene glycol. Activity It administered in a
dose of 25 mg/kg, i.p. exhibited decrease
collagen content of liver and increase in body
weight in chlorpromazine damage (0.25 mg/gm,
i.p.) in rats. The alcoholic extract produced
decrease in alkaline phosphatase value in rats
against CCl4 induced liver cirrhosis.   Reference
(1) Pandey, V.N. 1980 Evaluation of the
effects of indigenous drugs Kutaki, Kakamachi,
Kasani and Rohitaka against experimentally
induced chlorpromazine damage in albino rats, J.
Res. Ayur. Siddha (1) 77-105. (2)  Pandey,
V.N. 1979 Effect of indigenous drugs in the
management of certain liver disorders. A thesis
submitted for Doctor of Philosophy, BHU,
Varanasi.
62
Bhumyamalaki (Phyllanthus niruri)   Parts form
Extract of whole plant Activity The plant is
potentially effective against infective hepatitis
both experimentally and in clinical conditions as
out of 161 patients 101 cases were
cured. Ref Ramanan, M.V. and Sainansis, G.S.,
1962 Drugs in infective hepatic, Indian J.
Pharm. 24 (2) 34.
63
ANTI-ASTHAMATIC DRUGS
TULSI (OCIMUM SANCTUM) The anti-asthmatic
potential of sanctum leaves was also evaluated in
experimental models. The alcoholic extract of
leaves was found to protect guinea pigs against
histamine and Acacia arabica induced asthma.
The extract also significantly inhibited
histamine induced spasms in guinea pig tracheal
chain preparation.Ref. Palit, G. et al., 1983
An experimental evaluation of anti-asthmatic
plant drugs from the ancient Ayurvedic medicine.
Aspects Allergy Immunol 16, 36.
64
SIRISA (ALBIZIA LEBBEK) The drug partially
protected guinea pigs against histamine as well
as acetylcholine induced bronchospasm suggesting
antihistaminic action.Ref1. News Letter
Central Council for Research in Ayurveda and
Siddha. In the treatment of bronchial asthma
2(5) 1-2, 1979.2. Tripathi, S.N. and Shukla,
P. 1979 Effect of histamine and A. lebbcok on
pig adrenal glands. Indian J. Exptl. Biol. 17(9)
915-17.
65
VASA (ADHATODA VASICA) Vasicinone, a
bronchodilator alkaloid, identical with
qinazolone, was isolated in crystalline form from
leaves of A. vasica. The compound tested on
tracheal chain perfused lung and intact lungs of
guinea pigs produced bronchodilator properties
more pronounced against histamine induced broncho
constriction. Ref. Amin, A.H. 1961 Chemical
and pharmacological studies of vasicinone. A new
alkaloid from Adhatoda vasica Nees (Alembic
Chemical Works Co. Ltd., Baroda-3), Indian J.
Pharm. 23 117.
66
KANTAKARI (SOLANUM XANTHOCARPUM) Seed and
fruit extract of S. xanthocarpum exhibited
non-specific mild relaxation against histamine,
acetylcholine and barium chloride in guineapig
trancheal chain preparation.Ref. 1. Annual
Report, P.R.U., L.H.M.C., New Delhi.2. Bector,
N.P. et al., 1971 New approach to the treatment
of some chronic respiratory diseases Indian J.
Med. Res. 59 (5) 739-42.
67
PUSKARMULA (INULA RACEMOSA)- Specific studies
for bronchodilator properties on isolated trachea
were performed and found it as a potent
bronchodilator.- It possessed antihistaminic as
well as anti-5 HT activity suggesting its use on
bronchial asthma. Ref 1. Annual Report, P.R.U.
Lucknow.2. Singh, N. et al. Experimental
evaluation of antiasthmatic potentialities of I.
Racemosa (Pushkarmul). Qurt. J. Crude Drug Res.
18(2) 89-96, 1980.
68
Guggulu (Commiphora mukul) Parts form The
oleoresin portion and a steroidal compound
isolated from the petroleum ether extract of the
plant. Activity It possessed significant
anti-inflammatory activity in rat paw oedema
produced by carrageenin. The activity was dose
dependant and much more potent than that of the
resin fraction. exptl. Biol. 9, 403.  Reference
Gujral, M.L. et al., 1960 Anti-arthritic and
anti-inflammatory activity of Gum Guggulu
(Balsamodendron mukul Hook). Indian J. Physiol.
Pharmacol. 4, 267.Arora, R.B. et al, 1971
Isolation of crystalline steroidal compound from
Commiphora mukul and its anti-inflammatory
activity. Indian J.
69
Nirgundi (Vitex negundo) Parts form Ethyl
acetate extract of leaves and seeds. Activity V.
negundo in 50 mg/kg, p.o. produced significant
anti-inflammatory effect against carrageenin,
bradykinin and 5-HT induced rat hind paw oedema.
The extract exhibited significant
anti-inflammatory effect on sub-acute, chronic
and immunological studies as observed to inhibit
60 inhibition of granuloma pouch and 40
inhibition of cotton pellet implantation in rats
(50 mg/kg, p.o. for seven consecutive days)
suppressed primary, as well as secondary phase of
inflammation in rats by Freunds adjuvant (50
mg/kg, p.o. for 13 consecutive days). A compound
isolated from V. negundo leaves showed
significant anti-inflammatory property on acute
inflammation. It all protected turpentine
pleurisy in rats.  Ref Annual Reports, P.R.U.,
Calcutta.athore, R.S. 1973 Pharmacological
evaluation of seeds of Vitex negundo Linn. for
anti-inflammatory activity. Nagarjun 16(1) 35.
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ALZHEIMER'S DISEASE
Haridra (Curcuma longa)   Parts form The
petroleum ether extract and two of its fraction
i.e. A (Viscous oil) and B (Crystalline solid) of
the rhizomes of C. longa. Activity The results
of fraction were found to have significant
anti-inflammatory activity in rats which compared
favourably with hydro cortisone acetate and
phenylbutazone. Both the fractions reduced the
histamine content of the rat skin to about 50
percent of the control values, whereas
hydrocortisone acetate decreased the histamine
content to 58 percent of the controls. Curcumin,
isolated from the rhizomes was found to inhibit
the carrageenin induced oedema in rats as well
as in mice. Ref Arora, R.B. et al., 1970
Chemical, Pharmacological and Toxicological
studies of Curcuma longa (Turmeric). II Indo
Soviet sym. Chem.. Nat. Products including
Pharmacol, p. 133.
71
Amalaki (Emblica officinalis) Part form
Tannoid active principles of fruits consisting of
emblicanin A (37), emblicanin B(33),
punigluconin (12) and pedunculangin
(14). ActivityIt was investigated on the basis
of their effects on rat brain frontal cortical
and concentrations of the oxidative free radical
scavenging enzimes, superoxide ismutase (SOD),
catalase (CAT)and glutathione peroxidase(GPX) and
lipid roxidation.The active tannoids administered
in the doses of 5 and 10 mg/kg,I.p., and
deprenyl(2mg/kg,I.p.),induced an increase in both
frontal cortical and strital SOD,CAT and GPX
activity with concomitant decrease in lipid
peroxidationin these brain areas when
administered once daily for 7 days.

• The antioxidant activity may reside in the
  tannoids of the fruits, which have vit-c like
  properties.
• Reference Arunabh, B.et al.,1999 Antioxidant
  activity of active tannoids principles of Emblica
  officinalis (amla).I.J.Expol. Biology,vol.37(7),
  p.676-680.

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KARAVELLAKA ( Momordica charantia ) Fresh
green fruits of M. charantia were dried, powdered
and was administered to alloxamized rabbits in
doses of 0.25, 0.5 and 1.5 g./kg. P.o. It
showed significant lowering of blood glucose
level after 10 hours of administration.Ref.
Akhtar, M.S. et al., 1981, Effect of M. charantia
on blood sugar level of normal and alloxan
diabetic rabbits, plants med. 42 (3) 205-12.
DIABETES MELLITUS
73
Mesashringi -Gymnema sylvestre The alcoholic
extract of the leaves inhibited hyperglycaemia of
the 3rd hour (one and half hour after glucose
administration) in albino rats rendered
hyperglycaemic by anterior pituitary
extract.Ref. Gupta, S.S. and Seth, C.B., 1962
Experimental studies on pituitary diabetes,
part-III. Effect of indigenous anti-diabetic
drugs against the acute hyperglycaemic response
of anterior pituitary extract in glucose fed
albino rats. Ind. J. Med. Res. 51, 716.
74
Jambu (Syzygium cumini) Aqueous extract of
fruits in a dose of 48 kg. P.O. exhibited
significant hypoglycaemic effect (30) on fasting
rabbits. Similar effect was obtained in GTT
studies.Ref. Shrotri D.S. et al., 1963,
Investigations of the hypoglycaemic properties of
E. Jambolana. Ind. J. Med. Res. 51(5) 464-67.
75
BILVA (Aegle marmelos) The plant exhibited
significant hypoglycaemic effect against
streptozotocin treated hyperglycaemic
rats.Ref. Chakraborty, T. and Podar, G.
Herbal drug in diabetes, Part-I. Hypoglycaemic
activity of indigenous plans in streptozotocin
induced diabetes rats, J. Inst. Chem. (India) 56
(Pt.I) 20-22, 1984.
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ARJUNA (Terminalia arjuna) It induces a
dose-dependent decrease in blood pressure and
heart rate and inhibits carotid occlusion
response without affecting the pressure
responses. It has also been demonstrated that
the hypotensive and bradycardic effects are
mainly of central origin. Ref. Srivastava
R.D., Dwivedi S., Srinivasan K.K Indian Drugs
1992 29 144.
ANTI HYPERTENSIVE DRUGS
77
MANJISTHA (Rubia cordifolia) Methanolic
extract of R. cordifolia (whole plant) in doses
of 100 and 600 mg/kg/I.p./day when administered
in p. 388 lymphocytic leukemic mice exhibited
anti-cancer activity which was comparable to
5-Iluorouracil, a drug, used against gastric
cancer.Ref. Adwanker, M.K. et al., 1980
Anti-cancer activity of the extracts of R.
cordifolia in rats. Indian J. Exptl. Biol. 18(1)
102.5
ANTI CANCER DRUGS
78
CHITRAKA (Plumbago zeylanica) Plumbagin
obtained from root of P. zeylanica, administered
in a dose of 2 mg/kg, I.p. and orally in wister
rats induced with fibrosarcoma (by SC
implantation of milipore filter disc impregnated
with 20 methyl cholanthrene in paraffin oil (50
suspension) showed 10 and 60 regression of
tumour respectively. Ref. Krishnaswamy, M. and
Purushothaman, K.K. Plumbagin a study of its
anticancer, antibacterial and antifungal
properties, Indian J. Exptl. Biol. 18 (8)
875-877, 1980.
79
PASANBHEDA (Bergenia ligulata) The alcoholic
extract of the rhizome showed anti-cancer
activity in walker carcinosarcoma 256 in
rats.Ref. Dhar et al., 1968, Screening of
Indian Plants for biological activity, Part-I,
Indian J. Exptl. Biol. 6, 232.
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• POSSIBLE AREAS FOR COLLABORATION
• The international industry , considering
  the areas of strength may join hands and
  participate in the development of different
  dosage forms / unique drug delivery systems of
  single plant based drugs/formulations having
  diversified effects ,useful in multiple clinical
  conditions and chronic refractory conditions viz.
• Hypertension
• Anxiety Neurosis /Stress Syndrome
• Diabetes
• Malaria
• HIV/AIDS
• Cancer
• Obesity
• Rheumatoid Arthritis
• Psychological disorders
• Geriatric problems
• Psoriasis
• Life style disorders
• for the benefit of global humanity at large

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Thank You