IL18 Levels and Metabolic Syndrome: Summary Data

1
IL-18 Levels and Metabolic Syndrome Summary
Data

• Hung et al. Arterioscler Thromb Vasc Biol.
  2005251268-1273.

2
IL-18 and Metabolic Syndrome
Background

• Regulator of innate and acquired immune
• responses
• Proinflammatory cytokine
• Possible role in plaque destabilization
• Associated with cardiovascular death
• CAD patients
• Healthy Patients
• Stimulates production TNF-a and IL-6

Hung et al. Arterioscler Thromb Vasc Biol.
2005251268-1273.
3
IL-18 and Metabolic Syndrome
Background

• IL-18 levels associated with
• Adiposity
• Insulin Resistance
• Type 2 Diabetes Mellitus
• Unknown whether IL-18 levels were predictive of
  metabolic syndrome independent of obesity and
  insulin resistance.

Hung et al. Arterioscler Thromb Vasc Biol.
2005251268-1273.
4
IL-18 and Metabolic Syndrome
Study population

• Cross-sectional community-population
• Perth, Australia
• Sub-study of the Carotid Ultrasound Disease
  Assessment Study (CUDAS)

Hung et al. Arterioscler Thromb Vasc Biol.
2005251268-1273.
5
IL-18 and Metabolic Syndrome
Primary Outcome

• Metabolic Syndrome (defined by NCEP ATPIII
  criteria)
• High triglycerides
• Abdominal obesity
• Low HDL cholesterol
• Hypertension
• Insulin resistance, with or without glucose
  intolerance

Hung et al. Arterioscler Thromb Vasc Biol.
2005251268-1273.
6
IL-18 and Metabolic Syndrome
Multivariate Adjusted Odds Ratios for Metabolic
Syndrome According to Tertile Levels of CRP, IL-6
and IL-18
trend P Values
Hung et al. Arterioscler Thromb Vasc Biol.
2005251268-1273.
7
IL-18 and Metabolic Syndrome
Summary

• IL-18 independent risk factor of metabolic
  syndrome
• Independent of insulin resistance and obesity
• hs-CRP and IL-6 levels did not diminish risk
  associated with IL-18

Hung et al. Arterioscler Thromb Vasc Biol.
2005251268-1273.