ChE 742 Membrane Based Bioseparations

1
ChE 742Membrane Based Bioseparations

• Instructor
• Dr. Raja Ghosh
• JHE-374B
• Ext. 27415
• Email rghosh_at_mcmaster.ca
• 9 lectures 3-4 tutorials
• Fridays                 330-530 pm

2
Course outline

• Bioseparations engineering
• Introduction to membranes and membrane processes
• Bioseparation using ultrafiltration
• Bioseparation using adsorptive membranes

Course material
Text Protein Bioseparation Using Ultrafiltration
Theory Applications and new Developments, R.
Ghosh, Imperial College Press (2003) ISBN
1860943179 (for sections 1, 2 and 3) Review
papers (for section 4)
3
Assessment

• One written examination at the end of the course
  worth 60 of total marks
• 80 numerical problems 20 theory questions
• Open book/open notes exam
• Any type of calculator can be used in the exam
• Term paper worth 20 of total marks
• Term paper presentation worth 5 of total marks
• 3 assignments worth 5 of total marks each

4
Bioseparations engineering1 lecture

• Introduction
• Biological products
• Bioseparation requirements
• Economic importance of bioseparations engineering
• Strategies for bioseparation
• Bioseparation methods

5
Introduction to membranes and membrane
processes2 lectures

• Membrane material and chemistry
• Membrane structure and morphology
• Membrane characterization
• Driving force in membrane separation processes
• Membrane processes that separate primarily based
  on size
• Membrane processes that separate based on
  principles other than size
• Membrane devices
• Modes of operation.

6
Bioseparation using ultrafiltration4 lectures

• Introduction to ultrafiltration applications
  advantages over competing technologies permeate
  flux and membrane transport models membrane
  fouling critical flux concept concentration
  polarization enhancement of permeate flux
  transport of proteins and other biological
  macromolecules through membranes membrane
  rejection and sieving coefficients selectivity
  of separation protein concentration processes
  protein clarification processes protein
  desalting and diafiltration protein
  fractionation processes modes of operation
  challenges and new developments.

7
Bioseparation using adsorptive membranes1 lecture

• Introduction
• Advantages of using adsorptive membranes
• Membrane material
• Separation chemistries
• Devices
• Applications
• Challenges and new developments.