Potential Health Disturbances With ProlactinElevating Antipsychotic Agents

1
Potential Health Disturbances With
Prolactin-Elevating Antipsychotic Agents
Men
Women

• Short-Term
• Loss of libido
• Erectile dysfunction
• Ejaculatory dysfunction
• Reduced spermatogenesis
• Gynecomastia
• Long-Term
• Decreased bone density
• Mediated by relative or absolute deficiency of
  testosterone
• Cardiovascular disease?
• Depression?

• Short-Term
• Menstrual disturbances
• Galactorrhea
• Breast engorgement
• Sexual dysfunction
• Infertility
• Long-Term
• Decreased bone density
• Mediated by relative or absolute deficiency of
  estrogen
• Cardiovascular disease?
• Cancer (breast, endometrial)?
• Depression?

? few data available
Maguire GA. J Clin Psychiatry. 200263(suppl
4)56-62.