PowerPoint Poster Template

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HMMatch Peptide Identification by Spectral
Matching of Tandem Mass Spectra Using Hidden
Markov Models
US HUPO
Xue Wu1, Chau-Wen Tseng1, Nathan J.
Edwards21Department of Computer Science,
University of Maryland, College Park2Dept. of
Biochemistry and Mol. Cell. Biology, Georgetown
Medical Center
Peptide Identification Viterbi Score p-value
Introduction
HMMs Capture Consensus and Variation
Model Extrapolation To Related Peptides
Datasets DLA, AVM, and 3 one? Top row is
viterbi, second row is p-value and last row is
extrapolation. Room for 3 x 3 plots.
Observations

• HMM-based spectral matching can be used to
  identify peptides.
• HMMs can complement existing MS search engines
  to improve identification accuracy.
• Growing mass spectra libraries can improve the
  applicability accuracy of HMM-based peptide
  identification algorithms.

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