Translocation

1
Translocation

• Segment of one chromosome breaks off and attaches
  to another chromosome.
• Unbalanced translocation
• Balanced translocation
• Adjacent 1 2
• Alternative
• Robertsonian translocation

2
KC 8.25 (p213)

• A woman receives genetic counselling after having
  2 miscarriages. Cytogenetic studies indicate that
  she has a 2/3 translocation.
• Normal 2 A B . C D
• Normal 3 E F . G H
• 2/3 A B . G H E F . C D

3

• What is this abnormality called?
• Will this women be phenotypically normal?
• Demonstrate how her chromosomes will pair during
  meiosis?
• What is the probability that the next pregnancy
  will also end in a miscarriage?