Todays topics

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Todays topics

• Tumor suppressors, cont
• APC
• Adherens junctions
• Beta-catenin
• TGFbeta
• smad transcription factors
• Vogelgram

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Focus on 2 types of cancer

• Inherited
• FAP (familial adenomatous poliposis)
• Examine precursor lesions, follow cancer
  progression from hyperplasia to frank carcinoma.
• Spontaneous
• Colon Cancer

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Familial Adenomatous Poliposis (FAP)
FAP colon with 100s of polyps
Normal colon
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Normal, differentiated cell
hyperproliferative cell immortalized but
noninvasive transformed
(hyperplasia)
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Conacci-Sorrell et al, JCI (109) 2002 987-991
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Normal adenocarcinoma
Colon carcinoma anti-beta-catenin
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Todays topics

• Tumor suppressors, cont
• APC
• Adherens junctions
• Beta-catenin
• TGFbeta
• smad transcription factors
• Vogelgram

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