Significance of

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Significance of Unofficial Ibogaine Treatment
Scenes

• The existence of these scenes indicates demand
  for alternatives to existing treatment options.
• Averse events including fatalities indicate the
  need for appropriate prospective medical
  evaluation of patients, monitoring within the
  treatment, and reliable formulations of ibogaine.
• Anecdotal or case report evidence suggests a
  possible neurobiological drug action.
• All of the above strongly support the need for
  appropriate clinical trials to evaluate safety
  and efficacy in order to gain official approval

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1. Alper, K.R., Beal D., and Kaplan C.D. (2001).
A Contemporary History of Ibogaine in the United
States and Europe. In Ibogaine Proceedings of
the First International Conference (The Alkaloids
Volume 56), pp. 249-281. Academic Press, San
Diego, California.2. Lotsof, H.S., and
Alexander N.E. (2001). Case studies of ibogaine
treatment implications for patient management
strategies. In Ibogaine Proceedings of the First
International Conference (The Alkaloids Volume
56), pp. 293-313. Academic Press, San Diego,
California.3. Alper, KR, Lotsof, HS, Frenken,
GMN, Luciano, DJ, and Bastiaans, J. Treatment of
Acute Opioid Withdrawal with Ibogaine. American
Journal on Addictions 8 234-242,
1999.4. Frenken G. (2001). From the roots up
ibogaine and addict self-help. In Ibogaine
Proceedings of the First International Conference
(The Alkaloids Volume 56), pp. 283-292, Academic
Press, San Diego, California.5. Mash, D.C.,
Kovera A. , Pablo J., Tyndale R., Ervin F.R.,
Kamlet J.D., and Hearn W.L. (2001). Ibogaine in
the Treatment of Heroin Withdrawal Ibogaine
Proceedings of the First International Conference
(The Alkaloids Volume 56), (K. Alper and S.D.
Glick Eds.), pp. 155-171. Academic Press, San
Diego, California.6. Stolarof MJ. The Secret
Chief. (1997) Multidisciplinary Association for
Psychedelic Studies, Charlotte NC, 144
pages.7. Kastelic , A. Self-Help Use of
ibogaine in Slovenia Presented at the First
International Conference on Ibogaine. New York,
NY, Nov. 5 1999.
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Reports of Ibogaine Treatment in Humans

• Case studies presented to NIDA in March 1995 41
  individuals receiving a total of 52 treatments
• Published case reports (high degree of overlap
  with the above) describing a total of 56
  treatments
• Open label prospective study N32 (Mash et al.)

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Published Ibogaine Case Studies

• One paper describing 33 treatments for opioid
  dependence complete resolution of withdrawal
  signs and absence of drug-seeking behavior in 25
  (76)1.
• Total of 13 treatments, mainly for opioid
  dependence, in four additional papers2,3,4,5.
• 1. Alper, KR, Lotsof, HS, Frenken, GMN, Luciano,
  DJ, and Bastiaans, J (1999). Treatment of Acute
  Opioid Withdrawal with Ibogaine. American Journal
  on Addictions 8 234-242.2. Cantor, M. (1990).
  Interviews ibogaine treated addicts''. The
  Truth Seeker 117(5), 23-26. 3. Luciano, DJ.
  (1998). Observations on treatment with Ibogaine.
  American Journal on Addictions 7, 89-90.4.
  Sheppard, S.G. (1994). A preliminary
  investigation of ibogaine case reports and
  recommendations for further study. J.Subst.Abuse
  Treat. 11, 379-385.5. Sisko, B. (1993).
  Interrupting drug dependency with ibogaine a
  summary four case histories. Multidisciplinary
  Association For Psychedelic Studies (MAPS)
  Newsletter 4 15-24.

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Drug Abstinence Following Ibogaine Treatment
(unpublished, presented to NIDA March 1995)
Reported Time Interval of Post- treatment Drug
Abstinence N ()
lt2 months 15 (29)
2 to lt6 months 15 (29)
6 months to lt1 year 7 (13)
1 year 10 (19)
Not determined 5 (10)
Alper, K.R. (2001). Ibogaine A Review. In
Ibogaine Proceedings of the First International
Conference (The Alkaloids Volume 56), (K. R.
Alper and S.D. Glick, Eds.), pp. 1-38. Academic
Press, San Diego, California.
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Table 1 from Alper, KR, Lotsof, HS, Frenken,
GMN, Luciano, DJ, and Bastiaans, J. Treatment of
Acute Opioid Withdrawal with Ibogaine. American
Journal on Addictions 8 234-242, 1999.
Retrospective Case Series From Early1960s U.S.
and Late 1980s-Early 1990s Dutch Informal
Scenes Subjects
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Table 2 from Alper, KR, Lotsof, HS, Frenken,
GMN, Luciano, DJ, and Bastiaans, J. Treatment of
Acute Opioid Withdrawal with Ibogaine. American
Journal on Addictions 8 234-242, 1999.
Retrospective Case Series From Early1960s U.S.
and Late 1980s-Early 1990s Dutch Informal
Scenes Outcomes
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Prospective Open Label Study (Mash et al. 2001) 1

• 32 patients treated for opioid (heroin or
  methadone) withdrawal.
• Withdrawal Symptoms measured using the Objective
  Opiate Withdrawal Scale (OOWS)
• Fixed dose of 800 mg ibogaine HCl given
  approximately 12 hours after the last opiate dose
• OOWS significantly reduced at 12 and 24 hours
  post ibogaine administration the level of
  discomfort at these acute relative to
  post-treatment time points was as low as the
  level seen 1 week later. Objective signs of
  opiate withdrawal rarely seen and none increased
  at later time points.
• Decreased craving at lt72 hours post-treatment
  these reductions were maintained at 6 to 9 days
  post-treatment
• Depression scores reduced relative to
  pre-treatment at 6 to 9 days and 1 month
  post-treatment
• 1. Mash, D.C., Kovera A. , Pablo J., Tyndale R.,
  Ervin F.R., Kamlet J.D., and Hearn W.L. (2001).
  Ibogaine in the Treatment of Heroin Withdrawal
  in Ibogaine Proceedings of the First
  International Conference (The Alkaloids Volume
  56), (K. Alper and S.D. Glick Eds.), pp. 155-171.
  Academic Press, San Diego, California.

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Disease-Specific Advocacy
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Examples of Disease Specific Advocacy

• HIV Aids Coalition to Unleash Power (ACT UP)
  Treatment Action Group (TAG)
• Opiate Dependence Dutch Junkiebond, Danish Drug
  Users Union
• Psychiatric Disorders National Alliance for the
  Mentally Ill (NAMI)

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Nico AdriaansorganizerDutch Addict Self-Help
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• Political Advocacy Graphics