Flucoral

1
Flucoral

• Pharmacological Composition
• Each capsule containing 150mg Fluconazole.
• Fluconazole is a broad spectrum Systemic
  Antifungal

2
Flucoral

• Mechanism of action
• Inhibition of cytochrome P-450?Impairment of
  Ergosterol synthesis in the fungal cell
  membrane?Interfers with fungal cell membrane
  function growth?stop the fungal growth
• N.B
• Fluconazole is highly selective inhibitor to
  fungal cytochrome P-450 and doesn't affect on
  liver cytochrome P-450

3
Flucoral

• Pharmacokinetics
• The bioavailability of orally administered
  Fluconazole is over 90
• Absorption of fluconazole is unaffected by food
  or gastric acidity

4
Flucoral

• Pharmacokinetics
• Peak plasma concentrations (C-max) occur between
  1 and 2 hours with a terminal plasma elimination
  half-life of approximately 30 hours after oral
  administration

5
Flucoral

• Pharmacokinetics
• Fluconazole lipophillicity will achieve tissue
  levels exceeding the required MICs for all
  pathognomonic fungi for a complete week.

6
Flucoral
Effective Against Candida Species Infection At
Wide Range Of Body Sites And Tissues.
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Flucoral
8
Flucoral
9

• Flucoral

• Pharmacokinetics
• Fluconazole(FLUCORAL) is cleared primarily by
  renal excretion, with approximately 80 of the
  administered dose appearing in the urine as
  unchanged drug. About 11 of the dose is excreted
  in the urine as metabolites.

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Flucoral

• Excellent Eradication
• Flucoral is well established as a first line
  management option for the treatment of localized
  and systemic C.albicans infections.
• Micheal V. MartinJournal of Antimicrobial
  Chemotherapy (1999) 44.429-437

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Pityriasis Versicolor
12
Flucoral

• Excellent eradication rates in PityriasisVersicolo
  r
• Single dose fluconazole Vs Itraconazole

cure improvement rates
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Onychomycosis
14
Flucoral

• Excellent eradication rates in Onychomycosis

cure improvement rates
15
Flucoral
16
Flucoral
17
Flucoral

• Flucoral penetrates the nails and persists after
  twice weekly doses for 6 months in toenails and
  fingernails
• Amalia del Palacio et al ,dermatophytosis
  treatment (2000).Madrid,Spain

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• Indications
• 1 tinea Capitis.

2 Tinea cruris
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• Tinea Barbe.

• Tinea Corporis.

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• Tinea Pedis.

Tinea Versicolor.
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• Onychomycosis.

Candidiasis.
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• Flucoral

• Safety
• Fluconazole is contraindicated in lactating women
  and category C in pregnant women.

23
Flucoral
Monitoring of liver enzymes is not recommended
during therapy with fluconazole (FLUCORAL)
American Family Physician,February 15,2001Volume
63,Number 4
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Flucoral

• Itraconazole is not suitable for the routine
  treatment of infections in patients with raised
  liver enzymes,history of liver diseases when
  treatment prolonged (gt1 month) liver enzyme
  monitoring should be undertaken
• Journal of antimicrobial chemotherapy.1999

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Flucoral

• Flucoral is available as a box containing 2
  capsules each containing Fluconazole 150mg with a
  price of 14.60 LE.

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Thank You