HIGHLIGHT RESULTS: PROPATH

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• HIGHLIGHT RESULTS PROPATH
• Project Co-ordinator Prof. Luc De Vuyst
  (ldvuyst_at_vub.ac.be)
• The inhibitory activity of bifidobacteria towards
  Gram-negative, gastrointestinal pathogens is
  solely due to the production of organic acids, in
  particular acetic acid and lactic acid. Prebiotic
  inulin-type fructans might modulate the
  production of organic acids by lactobacilli and
  bifidobacteria in the gastrointestinal tract,
  underlying their potential activity towards
  pathogenic bacteria.
• Lactic acid has an important role in the activity
  of lactobacilli against Salmonella Typhimurium.
  Certain lactobacilli produce heat-stable,
  non-proteinaceous, specific, anti-Salmonella
  compounds, which are active at low pH and in the
  presence of lactic acid.
• 3) Lactobacillus johnsonii La1 produces a
  bacteriocin, named lactacin Fa, inhibitory to
  lactobacilli. The anti-H. pylori activity
  probably consists of or is depending on a mixture
  of low-molecular-mass metabolites and/or
  protease-sensitive compounds/bacteriocin(s).
• 4) Lactobacillus johnsonii La1, Lactobacillus
  casei Shirota, and Lactobacillus amylovorus DCE
  471 significantly decrease H. pylori binding to
  cultured human gastric adenocarcinoma AGS cells.
  Administration of Lb. johnsonii La1 to mice
  results in a significant delay of both chronic
  and chronic-active gastritis.
• 5) Some lactobacilli such as Lactobacillus
  johnsonii La1, Lactobacillus casei Shirota, and
  Lactobacillus plantarum ACA-DC 287 strongly
  inhibit the invasion of S. Typhimurium SL1344
  into cultured human enterocyte-like Caco-2 cells.
  Reduced S. Typhimurium levels are observed in the
  gastrointestinal tract and tissues of
  Salmonella-infected mice after administration of
  cultures of Lb. casei Shirota and Lb. fermentum
  ACA-DC 179.