Sekcija za zoonoze SVD

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Sekcija za zoonoze SVD Akademija SVD Fakultet
veterinarske medicine
SIMPOZIJUM o TULAREMIJI
Beograd, 21.12.2002
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Istorija tularemije.
What is the history of tularemia?
ta je tularemije?
What is tularemia?
Koji su simptomi tularemije?
Koje su fome tularemije?
What are the symptoms of tularemia?
What are the types of tularemia?
Kako se prenosi tularemija?
How is tularemia transmitted?
Tularemija- bioloko borbeno sredstvo?
What are the possible effects of a bioterrorist
attack?
Dijagnostika...
Terapija...
Labolatory diagnostic of tularemia...
What is the treatment for tularemia?
Mortalitet...
What is the mortality associated with tularemia?
Vakcine?
Is there a vaccine for tularemia?
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Rairenost u svetu
SAD
Severna Evropa, Ceka, Slovacka, panija,
Balkan...
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Disease OutbreaksReported25 January
2002Tularemia in Kosovo - UpdateAs of 24
January 2002, the Institute of Public Health
(IPH), Pristina, has reported 496 suspected cases
of tularemia since the outbreak began on 1
November 2001. Onehundred and nine of these
cases have been laboratory confirmed. There have
been no deaths to date (see previous report).
Measures for case management, environmental
control and health education are continuing. WHO
Collaborating Centre, Istituto Superiore di
Sanità, Italy and the Germancomponent of Kosovo
Force (K-FOR) are assisting the IPH by providing
reagents for diagnostic tests. Tularemia,
which is endemic in many parts of the world,
including north America, eastern Europe, China,
Japan and Scandinavia, is a bacterial disease
normallytransmitted from animal hosts and has a
variety of clinical manifestations. Symptoms
include high fever and body aches, swollen glands
and difficulty with swallowing,which continue
over a period of a couple of weeks.
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Disease OutbreaksReported17 January
2002Tularemia in KosovoAs of 17 January, the
Institute of Public Health (IPH), Pristina, has
reported 282 suspected cases of tularemia since
the outbreak began on 1 November 2001. Fifty-nine
ofthese cases have been laboratory confirmed.
There have been no deaths to date. The majority
of cases were detected in rural areas, mainly in
the Lipjlan, Ferijaz andPristine municipalities.
The patients' age range is between 16-44 years of
age.Tularemia, which is endemic in many parts of
the world, including north America, eastern
Europe, China, Japan and Scandinavia, is a
bacterial disease normallytransmitted from
animal hosts and has a variety of clinical
manifestations. Symptoms include high fever and
body aches, swollen glands and difficulty with
swallowing,which continue over a period of a
couple of weeks. The investigation of the
outbreak continues, and measures for case
management, environmental control and health
education are in place.
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Disease Outbreaks Reported 6 February
2002 Tularemia in Kosovo- Update 2 As of 5
February 2002, the Institute of Public Health
(IPH), Pristina, has reported 715 cases of
tularemia since the outbreak began on 1 November
2001. One hundred and seventy cases have been
laboratory confirmed, while 404 suspected cases
were found to be negative. An additional 141
suspected cases remain under laboratory
and epidemiological investigation. There have
been no deaths to date (see previous report).
Measures for case management, environmental
control and health education are continuing.
Tularemia, which is endemic in many parts of
the world, including north America, eastern
Europe, China, Japan and Scandinavia, is a
bacterial disease normally transmitted from
animal hosts and has a variety of clinical
manifestations. Symptoms include high fever and
body aches, swollen glands and difficulty with
swallowing, which continue over a period of a
couple of weeks.
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Rezervoari i vektori
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Kontagioznost --- slaba Contagious ---
no   Infektivne doze --- 10-50 bakterija Infective
dose ---10-50 organisms   Inkubacija ---1-21 dan
(prosecno 3-5 dana) Incubation period ---1-21
days (average3-5 days)   Trajanje bolesti ---
oko 2 nedelje Duration of illness --- 2
weeks   Smrtnost --- leceni nisko neleceni
osrednje Mortality --- treated low untreated
moderate Odrivost --- mesecima na vecini
lokaliteta Persistence of organism --- months in
moist soil
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Level a Procedures Nivo i procedure Francisel
la tularensis   Ovo je opasan, visoko virulentan
organizam sa kojim treba manipulsati
oprezno. This is a dangerous, highly virulent
organism and it should not be manipulated at
the bench. 
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Francisella tularensis Gram stain Poorly
staining, tiny Gram-negative coccobacilli
Growth Characteristics   Fastidious, requires
cysteine for robust growth Cysteine Heart Agar
(CHA) is ideal   Enriched chocolate agar 9
sheep blood cysteine   Not part of Level A
routine procedures
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Klinicke manifestacije bolesti
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Pato-morfoloke promene
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Sekcija za zoonoze SVD Akademija SVD Fakultet
veterinarske medicine
SIMPOZIJUM o TULAREMIJI
Beograd, 21.12.2002
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Sekcija za zoonoze SVD Akademija SVD Fakultet
veterinarske medicine
SIMPOZIJUM o TULAREMIJI
Beograd, 21.12.2002