Simple Inheritance, Pedigrees,

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Simple Inheritance, Pedigrees, Karyotypes
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PedigreesPage 309

• Similar to family trees
• A graphic representation of genetic inheritance

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Pedigree Symbols
Female
Carrier Female
Affected Female
Mating
Male
Carrier Male
Affected Male
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Example of Pedigree
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Simple Recessively Inherited Disorders

• Disorder only seen if two recessive alleles are
  inherited.

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Cystic Fibrosis

• Common among white Americans
• About 1 in every 28 white Americans carrier the
  recessive allele
• Leads to mucus build up in the lungs and
  digestive tract
• Can be treated

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Tay-Sachs Disease

• Common among Ashkenazic Jews
• Leads to lipids accumulating in the central
  nervous system
• Children with disease can not control their
  bodily functions (muscles)

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Phenylketonuria (PKU)

• Common in Americans who descend from Norway,
  Sweden or Ireland.
• PKU children appear normal at first
• Leads to the build up of the amino acid
  phenylalanine
• Can lead to mental retardation

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Dominantly Inherited Traits

• Trait or Disorder seen if one dominant allele
  inherited

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Different Dominantly Inherited Traits

• Free Earlobes
• Hitchhikers Thumb

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Cleft Chin
Widows Peak
Polydactyl Hands
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Huntingtons Disease

• Dominantly Inherited
• Lethal (Deadly) Disorder that causes areas of the
  brain to break down
• Does not appear until person is in their 30s

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Karyotypes

• Chart of chromosomes used to diagnosis
  chromosomal disorders.
• Also used to determine gender

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Example Karyotype