Progesterone

1
Progestins
Progesterone
Progest-4-ene-3,20-dione
2
Functions of Progesterone

• Maintains pregnancy
• Inhibits follicular maturation and ovulation
• prevents spontaneous uterine contraction

3
Progesterone Biosynthesis and Metabolism
Cholesterol
Pregnenolone
Progesterone R
CH2CH2CH2CH(CH3)2
6a-hydroxy progesterone
20a/b-hydroxy
progesterone
5b-pregnane-diol
4
Progesterone Agonists
Derivatization in rings A, B and D
17a-hydroxy progesterone caproate
Megestrol acetate
Medroxyprogesterone acetate
Chlormadinone acetate
5
Progesterone Agonists
Testosterone Derivatives
Ethisterone
Dimethisterone
6
Progesterone Agonists
19-Nortestosterone Derivatives
Norethisterone
Norethindrone
Norethynodrel
Desogestrel
3-Ketodesogestrel
Ethynodiol diacetate
Norgestimate
Norgestrel
7
Progesterone Antagonist
Mifepristone
Onapristone