Diseases of the Epidermis

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Diseases of the Epidermis

• Ichthyoses vulgaris
• Psoriasis

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Ichthyosis vulgaris
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Ichthyosis Vulgaris (Fish-like Scales)
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Psoriasis
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Epidermal hyperplasia in a patient with psoriasis
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Proposed pathogenesis of psoriasis.
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Autoimmune Blistering Diseases

• Pemphigus vulgaris
• Bullous pemphigoid
• Dermatitis herpetiformis

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Role of Autoantibody in the Pathogenesis of
Pemphigus Vulgaris
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Biopsy of lesional skin in patient with pemphigus
vulgaris
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Demonstration of autoantibody in skin of a
patient with pemphigus vulgaris
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Bullous Pemphigoid

• A 65-year old white male presented with a 2 week
  history of erythematous pruritic plaques and
  blisters extensively distributed over the trunk
  and extremities. There was no involvement of
  mucuous membranes and the review of symptoms is
  negative for systemic complaints.

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Autoantibody Pathogenesis of Bullous Pemphigoid
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BP Subepidermal Blistering
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Dermatitis herpetiformis

• Gluten sensitivity resulting in plaques and small
  vesicles over the extensor surfaces of body

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Biopsy of Lesional Skin in Patient with
Dermatitis Herpetiformis
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Acne Vulgars

• Propionibacterium acnes

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Inflammation and Rupture
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Primary Neoplasms of Skin

• Melanoma
• Basal Cell Carcinoma
• Squamous Cell Carcinoma

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Radial Growth Phase Melanoma
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Radial Growth Phase Melanoma
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Vertical Growth Phase Melanoma
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Nodular Melanoma
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Lentigo Maligna Melanoma on Sun-Damaged Skin
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Acral Lentiginous Melanoma
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Verrucae are Warts Caused by Human Papillomavirus
(HPV)
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Basal Cell Carcinoma
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Squamous Cell Carcinoma
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Approximately 3 out of 10 Caucasians develop a
basal cell cancer within their lifetime.
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Path Key Words

• Actinic keratosis
• Basal cell carcinoma
• Bullous pemphigoid
• Dermatitis herpetiformis
• Epidermolysis bullosa
• Erythema multiforme
• Erythema nodosum
• Ichthyosis vulgaris
• Kaposi sarcoma

• Lentigo simplex
• Lichen planus
• Melanoma
• Psoriasis
• Scleroderma
• Squamous cell carcinoma
• Urticaria
• Urticaria pigmentosa
• Verruca vulgaris