MIGRANT STUDIES

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MIGRANT STUDIES

• Ronald E. LaPorte, Ph.D.
• Director, Disease Monitoring and
  Telecommunications WHO Collaborating Center,
  Professor of Epidemiology

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Questions

• What is a Migrant Study?
• How do Migrant Studies differ from Admixture
  Studies?
• What is the future for Admixture and Migrant
  Studies?

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Migrants
pilgrim refugee conquerors displaced people
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Migrant Studies
Studies taking advantage of migration to one
country by those from other countries with
different physical and biological environments,
cultural background and/or genetic makeup, and
different morbidity or mortality experience.
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From (KOFF) 1967 PITTSBURGH
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Growth of Racial/Ethnic Groups in U.S.A.
Percent
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The migration of human population provides a tool
for the study of the respective roles of host and
environmental factors in the development of
disease.
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Rise and Fall of Migrant Studies
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Migratory Patterns
Ireland,1817
Germany,1920
Poland, 1900
Jan Dorman
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Migration Patterns
England, 1979
Trevor Orchard
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Migratory Pattern
Quebec, 1820
France, 1819
Buffolo,NY
Pittsburgh,PA
Germany, 1880
Ron LaPorte
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1993 Refugees to U.S.
Eastern Europe,1,500
Former Soviet Union 52,000
East Asia 52,000
Africa 7,800
South East Asia 7,000
Latin America 3,500
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MIAMI
1950s
1970s
HAVANA
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Migrant Studies
Host Population
Source Population
Migrant Pop
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Incidence of Disease X in source, host, and
migrant populations
Environmental etiology
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Incidence of Disease X in source, host, and
migrant populations
Genetic etiology
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Migrants are almost never representative of their
native populations
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Existing Migrant Data
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Some example of IDDM incidence per 100000
Source Migrant
Chinese 7(Shanhai) 3(Hawaia)
Japanese 2 (some areas) 3 (Hawaia)
Jewish 6 (Israel) 15
(Canada) Mexican 1(Some areas) 10
(Colorado)
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Differences in Incidence, Migration vs Geographic
Variation
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Questions

• What is a Migrant Study?
• How do Migrant Studies differ from Admixture
  Studies?
• What is the future for Admixture and Migrant
  Studies?

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Admixture studies
Hybrid populations
H1
Parent population 1
Parent population 2
H2
H3
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Incidence of Diseases X in source and hybrid
populations
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Correlation of Incidence of Disease X and
admixture proportion
I
G
H
F
D
Incidence
E
B
C
A
Admixture proportion
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Migration Time Line
Showers
Culture
Genetics
1st Generation
Full Assimilation
2nd Generation
3rd Generation
Environmental Shower
Genetic Change
Cultural Change
Climate
Viruses
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Migration Time Line
1st Generation
3rd Generation
2nd Generation
Environmental Shower
Genetic Change
Cultural Change
Beginning Loss of Language Changes in Diet
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IDDM in Asian Populations
Ten fold Difference
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Questions

• What is a Migrant Study?
• How do Migrant Studies differ from Admixture
  Studies?
• What is the future for Admixture and Migrant
  Studies?

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Heritage Research The Next Generation of
Migrant Studies
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Heritage studies
Genetic factors
Environmental Factors
H1
Parent population 1
H2
H3
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IDDM Incidence in Latin America
Incidence per 100 000
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Iberian - heritage collaboration
NORTH and SOUTH AMERICA
SPAIN