IND

1
Military Infectious Disease Research
ProgramVaccine Status

• Influenza (WWII)
• Adenovirus (1970s Now out of production)
• Meningococcus (Following 60s)
• Japanese Encephalitis
• Hepatitis A
• Plasmodium falciparum (RTS,S)
• Shigella flexneri
• Campylobacter
• Enterotoxigenic E. coli (ETEC)
• HIV Vaccine (multiple)
• Dengue
• Hepatitis E
• Group B meningococcus
• Falciparum malaria blood stage (MSP1)
• Plasmodium falciparum DNA
• Plasmodium vivax
• Shigella sonnei, S. dysenteriae
• Campylobacter, ETEC (second generation)
• Hemorrhagic Fever with renal syndrome caused by
  Hantavirus

Licensed
4 Vaccines Licensed
Vaccines
IND
IND Exemptions for 10 Vaccines
6 Preclinical
Emerging
2
Military Infectious Disease Research
ProgramDrugs, Diagnostics and Other Protectants
Drugs

• Doxycycline for prophylaxis
• Halofantrine
• Mefloquine
• Malarone
• Tafenoquine for prophylaxis
• Pentostam for cutaneous leishmania
• Artelinic acid for MDR malaria

Licensed
4 Drugs Licensed
2 Drugs under IND
IND
Drugs
Emerging
1 Preclin
Diagnostics and Protectants
3 items Licensed

• Camouflage face paint-insect repellent
• Scrub typhus diagnostic
• Portable/expandable bednet
• Leishmania skin test (3 INDs)
• Malaria rapid diagnostic
• Shigella rapid diagnostic
• Leishmania Diagnostics
• Replacement for DEET
• Comprehensive ID diagnostic tests

Licensed
4 Dx tests under IND
IND
Emerging
3
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4
Emerging Medical BD Products

• VEE/EEE/WEE Combined Vaccine
• Staphylococcal Enterotoxins Vaccine
• Ricin Vaccine
• Common Diagnostic System for BD Threats and ID
  Diseases
• Next Generation Anthrax Vaccine

5
Medical Biological DefenseProducts in
Development (Projected Fielding)

• Smallpox Vaccine (Cell Culture Derived) - 2005
• Recombinant Plague Vaccine - 2006
• Venezuelan Equine Encephalitis Vaccine - 2008
• Tularemia Vaccine - 2008
• Recombinant Botulinum Vaccine - 2009
• Brucella Vaccine - 2010