Company profile

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Company profile
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Where you can find us
your partner in sophisticated organic chemistry
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VUOS ownership
                                                 
                             
 
AGROFERT HOLDING,a.s..
100
DEZA, a.s.
98,43
VÝZKUMNÝ ÚSTAV ORGANICKÝCH SYNTÉZ a.s. (VUOS)
100
100
SYNTESIA, a.s.
FATRA,a.s.
your partner in sophisticated organic chemistry
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History

• 1941 Foundation of Research Laboratories
• 1951 Research Laboratories becomes independent
• 1952 New name VUOS
• 1992-6 Voucher Privatisation-VUOS becomes Join
  stock company
• 1997 Affiliation of Synthesias RD to VUOS
• 1998 Aliachem a.s. and Unipetrol become majority
  shareholder of VUOS
• 2004 VUOS becomes 100 daughter company of
  Synthesia a.s.

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VUOS main businesses

• 1. Production Fine Chemicals
• 2. Research and Development
• 3. Special Services
• - Process Engineering
• - Analytics
• - Toxicology

your partner in sofisticated organic chemistry
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The Certificates of VUOS

• ISO 90012001
• Certificate of Accreditation for Certification of
  Products No. 229/2002
• Certificate of Accreditation No. 230/2002 Testing
  Laboratory No. 1057
• Certificate of Good Laboratory Practice
• Certificate on Compliance with Principles of Good
  Laboratory Practice
• Certificate on Compliance with Principles of Good
  Manufacturing Practice in laboratory

your partner in sofisticated organic chemistry
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Strong Points

• VUOS is located in area of long-lasting
  . chemical tradition
• Technological park is suitably located .
  outside urban area
• Complete infrastructure including special .
  services (fire brigade, health services, .
  security, etc.)
• Waste water treatment plant and landfill
• Cooperation with University of Pardubice

your partner in sofisticated organic chemistry
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Education structure
your partner in sofisticated organic chemistry
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Research Development

• pharmaceutical intermediates
• fine chemicals
• intermediates for microelectronics
• custom syntheses of chemical specialities
• dyes and pigments for special application

your partner in sofisticated organic chemistry
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Fine Chemicals Production
Wide range of quantities Grams
in laboratory Kilograms
in kilolab unit Metric tons
in production plant Hundreds of MT
in Synthesia
your partner in Fine Chemicals
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VUOS's technology / manufacture expertise
include
Key technologies and know-how
O
O
O

• catalytic hydrogenation
• phosgenation
• Halogenation
• adamantane chemistry
• Key chemistry
• aromates
• heterocycles
• adamantanes

O
H
H
O
C
N
N
N
H
2
your partner in Fine Chemicals
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VUOS's technology / manufacture expertise
include
dehydrohalogenation diazotisation elimination este
rification Friedel-Crafts reaction heterocyclic
synthesis hydrolysis reactions neutralisation nitr
ation nitriles syntheses oxidation
catalytic/chemical oxidation in liquid phase
rearrangement reduction with hydrazine and
sodium borohydride sulfonation

• acetylation
• aldolisation
• amidation
• alkylation
• amination
• amoxidation
• alkali fusion
• arylhydrazines syntheses
• azocoupling
• benzoylation
• chiral synthesis
• chlorination
• chlorosulfonation
• cyclisation
• Claisen condensation
• decarboxylation

your partner in Fine Chemicals
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Kilolab Unit
2x reactors, 250 and 650 l 2x High performance
rectification columns
Phosgenation
your partner in Fine Chemicals
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Kilolab Unit
20x glass reactors, 100 l each 6x glass lined
reactors (200 1,500 l) 2x evaporators 50 l /
h 4x stainless steel reactors (300 1,500
l) sufficient filtration and distillation
capacity
Multipurpose chemistry
your partner in Fine Chemicals
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Kilolab Unit
3x autoclaves 100 l each, 60, 120 and 130 bar,
up to 200C, Hastelloy C clad 1x autoclave 300
l, 120 bar, 140C, Hastelloy C clad 1x autoclave
700 l, 100 bar, 200oC, stainless steel 1x
autoclave 1,000 l, 10 bar, 140C, stainless steel
many autoclaves up to 10 l
Hydrogenation
your partner in Fine Chemicals
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Kilolab Unit
1 x glass reactor 50 l cooled down to 80C 1x
glasslined reactor for NaH reactions (250
l) 3x glass reactors 100l for RLi, Grignard
reactions
Low temperature, RLi, RMgX, NaH
your partner in Fine Chemicals
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Production Plant Equipment
45x glass lined reactors, total vol. 70,000 l
(500 5,000 l) 13x stainless steel reactors,
total vol. 22,000 l (1,000 3,000 l) 8x High
performance rectification columns sufficient
filtration capacity (nutsches, centrifuges)
computer controlled
Production Unit
your partner in Fine Chemicals
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Co-operation partner - FARMAK, a.s.

• FARMAK, a.s. is a globally active Czech
  pharmaceutical and chemical company focused on
  development, production and marketing of APIs,
  advanced intermediates and specialities, operated
  by 274 employees
• Key technologies and know-how

Heterocyclic and Grignard chemistry APIs under
cGMP FDA inspected facility ISO 9001, ISO 14001
certified DMF, CoS available
Range of services

• RD, cGMP Kilo-lab
• and Pilot-plant scale
• Large scale production

www.farmak.cz
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Co-operation partner -
Lucební závody Draslovka a.s.
Lucební závody Draslovka a.s. Kolín (LZD a.s.)
was established in 1906. LZD a.s. is a very
experienced company in cyano group (CN-)
chemistry and production of liquid HCN.
Key technologies and know-how
Catalytic process for production and operation
with HCN in gas and liquid form Production of
most custom synthesis that are based or involve a
step with CN- group Production of high quality of
solid NaCN, KCN, diphenylqunidine and special
gasses
Havlíckova 605 280 99 Kolín IV 420 321 335
111 www.draslovka.cz
Range of services
pilot scale( up to 250kg) Large scale production  
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Toxicology, Ecology and Analytics
your partner in Eco/toxicology and Analytics
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Analytical Techniques NMR Spectrometry Mass
Spectrometry ICP IR Spectroscopy Chromatography UV
-VIS
your partner in Eco/toxicology and Analytics
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Toxicology, Ecology and Analytics
Toxicology / ecotoxicology testing
Sampling, analysing, evaluation of production
waste streams (air pollution, effluents, solid
wastes hazards) Environmental Impact
Assessment Development/validation
of new specialised analytical methods
your partner in Eco/toxicology and Analytics
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REACH
Complete Offer of Services by VUOS-REACH
CONSULTING TESTING REGISTRATION
your partner in Eco/toxicology and Analytics
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Toxicology

• Testing of new chemicals for notification
• Testing of bio-active chemicals

your partner in Eco/toxicology and Analytics
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Contacts
General Manager Dr. Karel Novák Phone 420
46 682 2550 fax[phone] e-mailkarel.nova
k_at_vuos.com  Sales Manager Milo
Jesenský,Ph.D. Phone [phone] fax420
46 682 2976 e-mailmilos.jesensky_at_vuos.com  RD
Section Colorants Lubimír Kubác Phone420
46 682 2610 fax [phone] e-mail
lubomir.kubac_at_vuos.com RD Section Organics
Alois Kolonicný, Ph.D. Phone[phone]
3156 fax [phone] e-mailalois.kolonicny_at_
vuos.com Toxicology and Analytics Viktor
Mejstrík,Ph.D. Phone[phone] fax420
46 682 2975 e-mailviktor.mejstrik_at_vuos.com Proc
ess Engineering Lubo Víek Phone[phone]
5790 fax[phone] e-maillubos.visek_at_vuos.
com
www.vuos.com

Our team is ready for co-operation with you