The Neuroscience Behind Drugs of Abuse

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The Neuroscience Behind Drugs of Abuse
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Dopamine D2 Receptors are Lower in Addiction
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Reward Circuits
Non-Drug Abuser
DA D2 Receptor Availability
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Reward Circuits
control
addicted
Drug Abuser
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Decreases in Metabolism in Anterior Cingulate
Gyrus Orbito-Frontal Cortex (OFC)
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Impulsivity
Compulsive Drug Intake
control cocaine abuser
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The Memory for Drugs
Amygdalanot lit up
Amygdalaactivated
Front of Brain
Back of Brain
Nature Video
Cocaine Video
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ALCOHOL

• Especially toxic for females
• Permanent damage to liver, heart, brain,
  and possibly stomach
• Shrinkage of frontal cortex, even in
  teenage heavy drinkers

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Alcohol and the Brain
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INHALANTS

• Glues, paints, fuels, propellants
• Sudden sniffing death syndrome
• Permanent damage to lungs, liver, bone
  and brain

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How Inhalants Damage the Brain
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A. Brain B. Cerebral cortex C.
Cerebellum D. Opthalmic nerve
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Dextromethorphan (DXM, Robo, Skittles,
Triple C)
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Your Brain After Drugs
Normal
Cocaine Abuser (10 da)
Cocaine Abuser (100 da)
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Drugs Have Long-term Consequences
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For More Information
NIDA Public Information Office
301-443-1124 Or National Clearinghouse on
Alcohol and Drug Information (NCADI)
1-800-729-6686
www.nida.nih.gov www.drugabuse.gov
www.drugabuse.gov