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Dynamic System Model for Ventricular Cardiac Diastolic Function

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... model to characterize the normal functioning of the heart during diastole. ... Model the right ventricle during diastole using a dynamic system model ... – PowerPoint PPT presentation

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Title: Dynamic System Model for Ventricular Cardiac Diastolic Function


1
Dynamic System Model for Ventricular Cardiac
Diastolic Function
  • Project Proposal
  • Justin K. Gross
  • Project 18
  • University of Colorado at Boulder
  • Mechanical Engineering
  • MCEN 5208 Introduction to Research
  • Professor Oleg V. Vasilyev
  • Acknowledgements Professor Robin Shandas
  • Dr. Osama Mukdadi

2
Problem/Questions
  • To develop a mechanical systems model to
    characterize the normal functioning of the heart
    during diastole.
  • To alter this model to include heart pathologies.
  • Can knowledge of mechanical functioning of the
    heart be used to help diagnose heart pathologies?

3
Background
  • Right ventricle pumps deoxygenated blood to the
    lungs
  • Diastolic period when ventricles relax after
    systolic contraction and fill with blood
  • Flow through atrioventricular valves
  • Cardiac pathologies changes mechanical
    functioning
  • Clinicians look at flow across atrioventricular
    valve to aid in disease detection

4
Objectives
  • Model the right ventricle during diastole using a
    dynamic system model
  • Find parameters of the system
  • Understand heart functioning for healthy and
    unhealthy hearts
  • Which mechanical parameters change
  • Understand correlated physiological changes
  • Develop step towards a tool for diagnosis of
    heart disease

5
Methodology
  • Dynamic systems model of right ventricular
    diastolic function
  • One dimensional
  • Solve inverse problem using clinically obtained
    data
  • Blood transvalvular flow velocities
    (Echocardiography)
  • Tissue velocities (tissue Doppler)
  • Determination of parameters m, c, k using certain
    assumptions
  • Numerical data fitting using MATLAB
  • Nonlinear solver
  • Levenberg-Marquardt
  • Statistical analysis to validate model with
    actual cardiac data

Lisauskas JB, et al.
6
Timeline
7
References
  • Lisauskas JB, Singh J, Bowman AW, Kovacs SJ.
    Chamber properties from transmitral flow
    prediction of average and passive left
    ventricular diastolic stiffness. J Appl Physiol,
    91154-1622001.
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