NUCLEOPHILIC SUBSTITUTION REACTION

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NUCLEOPHILIC SUBSTITUTION REACTION
CARBOXYLIC ACID AND ITS DERIVATIVES
NUCLEOPHILIC ADDITION to a carbonyl group as the
first step
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NUCLEOPHILIC SUBSTITUTION REACTION
CARBOXYLIC ACID AND ITS DERIVATIVES
Rearrange the pi-bonding electron pair Move them
to the more electronegative oxygen. This
maintains the tetravalency of carbon.
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NUCLEOPHILIC SUBSTITUTION REACTION
CARBOXYLIC ACID AND ITS DERIVATIVES
Since X is a good leaving group, the negative
charge on the oxygen will be involved in ejecting
the group X and re-establish the CO bond thus
completing the reaction. ELIMINATION OF GROUP X
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NUCLEOPHILIC SUBSTITUTION REACTION
CARBOXYLIC ACID AND ITS DERIVATIVES
Overall process Nucleophilic Addition followed
by Elimination of X