Haplotype

1
Haplotype

• The genetic constitution of an individual
  chromosome
• a particular pattern of single nucleotide
  polymorphisms (SNPs) alleles along a region of a
  single chromosome

2
Recombination and particular haplotypes

• Recombination occurs preferentially in specific
  regions
• "recombination hotspots"
• "recombination cold spots" haplotype blocks
• Thus, alleles of a particular haplotype tend to
  be preserved and inherited together as they are
  stationed in close proximity on an area that is
  not subject for recombination.

3
Deducing from a haplotype

• "T C w b" haplotype associated with the disease
  
• "t C w b/ "T C W B" disease affected subjects
• " T c w b" /"t c W Bhealthy subjects
• What can be concluded about the identity of the
  allele involved in the disease?