RESEARCH NEEDS : BIOAVAILABILITY METHODOLOGY

1
RESEARCH NEEDS BIOAVAILABILITY METHODOLOGY
2
IN VITRO METHODOLOGIES

• Develop simple and reliable methods to screen
  bioavailability of dietary supplements
• Validate in vitro methods against human trials

3
In Vivo Methodologies

• Develop and use reference standards of specific
  nutrients and bioactive substances in human
  bioavailability trials
• Develop methods to measure fractional absorption
  of nutrients and bioactive substances
• Determine whether conventional approaches to
  estimate nutrient bioavailability work for active
  ingredients of botanicals

4
In Vivo Methodologies - 2

• Determine whether classical drug
  bioavailability tests are applicable for
  bioactive ingredients
• Develop methods to study absorption/bioavailabilit
  y of commercial supplements actual dose levels
  and tablet forms in the target population of
  intended use