Graduation Project I

1
Graduation Project I
Device for controllable administration of drug
dosage
Prepared By - Mona
Ibrahim 200002091
- Azza Al Hassani 200002019
- Asma Ahmed
200002020 - Hamda Al
Ketbi 199902209
- Moza Al Shamsi 199908356 Advisers
name - Dr. Yousef Haik
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Outline

• Introduction
• Background Theory
• Methods and Techniques
• Results and Discussions
• Conclusion

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Introduction
4
Project Description
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Objectives

• Design a blood testing mechanism
• Design a drug dispensing mechanism
• Design and construct a working prototype of the
  system

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• Motivation

• Frequent Monitoring
• Dose adjustment
• Reduce patient error
• Time saving
• Availability of a patient medical history
• Minimizing potential risks and liability
• Reduce visiting appointments which will reduce
  insurance payments.

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Background Theory
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Blood Clotting

• A natural process in which blood cells and fibrin
  strands clump together to stop bleeding

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Blood Coagulation Mechanism

• There are two well-recognized coagulation
  pathways
• Extrinsic (thromboplastin)
• Intrinsic (prothrombin/fibrongen)

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Prothrombine Time PT

• The time it takes plasma to clot.
• PT is reported in seconds

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International Normalization Ratio

• The ratio of the patient's clotting time to the
  mean reference value.

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Anticoagulants

• Medications that delay the coagulation of blood
• Some of these are
• Heparin
• Argatroban
• Hirudin
• Warfarin

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Warfarin

• Warfarin is probably the best known and
• most widely used oral anticoagulant. It is a
  non-habit forming medication used to limit the
  size of existing blood clots and to prevent
  formation of new blood clots in high-risk
  patients

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Methods and Techniques
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Design Process
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Market Analysis

• The ProTime System-PT-INR Testing
• The Harmony INR Monitoring System
• Coaguchek System
• INRatioPT Monitoring System

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Function Structure
Global device function
Overall function structure
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Specifications

• Measuring System
• Dispensing System

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Measuring system
Small sample volume 20 µL

• Disposable sample holder

• Measuring time is less than one minute

• Made of biocompatible materials

• Sensitive can measure less than 1 mg/ mL of
  Prothrombin

• Meet the International Biomedical Instrumentation
  standards

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Measuring system
Portable and easy to use

• Touch button operation

• Large, easy to read reporting screen

• Perform measurement automatically as soon as the
  sample is applied

Durable, Repeatable and Cost effective meter and
test strip
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Dispensing system
Durable
Store medicine
Cost effective
Loading medicine dump
Dispense one tablet at the time
Patient interference to the device is negligible
Time for dispensing to be less than 2 minutes
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Developing concepts
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Testing Morphological Chart
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Testing Methods
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RLC Testing Method
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Protein Separation Method
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Cantilever Beam Method
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Plasma Profile
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Measuring the distance moved
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Shear Stress
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Light Intensity
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Blood layer Thickness
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Contact Angle
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Flow in Pipes
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Piezoelectric
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Elisa
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Viscosity
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The charged Particle method
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Resistance Measurement using Y tube
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Drug Dispensing Device
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Dispensing Morphological Chart
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Dispensing Morphological Chart
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Dispensing Morphological Chart
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Dispensing Concept 1
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Dispensing Concept 2
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Dispensing Concept 3
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Communication Part
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Communication Morphological Chart
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Results and Discussions
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Feasibility study

• Cantilever beam method
• Light Intensity and plasma profile
• Measuring the distance moved

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Feasibility study

• Capacitance measurements
• Procedure 1 Measuring the voltage across the
  copper plates
• 
  with time

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Feasibility study

• Procedure 2 Measuring the capacitance across the
  copper
• plates
  with time

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Feasibility study

• Procedure 2 Measuring the capacitance across the
  copper
• plates
  with time for different INR values

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Feasibility study

• Contact angle measurements

Syringe
camera
sample stage
light source
Captive Bubble Contact Angle apparatus
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Feasibility study

• Surface Area method

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Feasibility study

• Protein Separation method

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Conclusion
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Future work

• Resuming investigating the testing methods
• Evaluating testing methods
• Selecting the proper and suitable testing method
• Selecting appropriate design for dispenser
• Building a prototype for the whole device