Implications for Research

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Implications for Research

• Future Research Agenda
• to Assure
• Evidence-based
• Medicine

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New England Journal of Medicine October 1985
The Nurses Health Study
These data support the hypothesis that the
postmenopausal use of estrogen reduces the risk
of severe coronary heart disease.
The Framingham Heart Study
No benefits from estrogen use were observed in
the study group in particular, mortality from
all causes and from cardiovascular disease did
not differ for estrogen users and nonusers.
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Long-Term Administration of HT
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Benefits
-

Risks
Fractures
Colorectal Cancer
Global Index gt 1
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• What is the impact of individual variations and
  reactions?
• Are there subsets of women who are at particular
  high risk, or might particularly benefit?

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• Would different dosages and/or route of
  administration change the risks or the benefits?
• Would different formulations and compounds have
  the same, or other effects?

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What about the issue of MENOPAUSAL SYMPTOMS ?
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A Short History of Hormone Therapy
1942 FDA approved estrogen for treatment of
menopausal symptoms
Estrogen causes uterine cancer
ESTROGEN
Progestins protect uterus
PROGESTIN
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• Cardiovascular Disease
• Osteoporosis
• Cancer
• Alzheimers Disease
• Menopausal Symptoms
• Alternatives to Hormone Therapy

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