Research in the Computational Sciences

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Research in the Computational Sciences

• John Rose

Defined as whatever I find interesting
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Bioinformatics

• Goal to understand
• the meaning of genomic information
• how that information is expressed
• Less prosaically, to understand the Book of
  Life
• In order to develop
• More effective treatments for disease
• New drug delivery systems
• GMOs

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Bioinformatics at USC

• Microarrays
• Temporal and spatial gene expression
• Provides information on gene involvement in a
  pathway or process

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Bioinformatics at USC

• Phylogenetics
• Essentially genealogical trees
• Goal identify and understand relationships
  between the many different kinds of life

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Bioinformatics at USC

• Phylogenetic Tree constructed from similarity
  matrix

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Philosophical Agents Long-term Mission Robustness
Context
Contributions

• Supports missions of greater complexity
• Reduces cost via autonomy
• Reduces impact of communication time lag
• Significantly enhances mission robustness

Philosophical Principles for Agents
Impact

• Do not harm the mission
• Do not harm mission participants
• Do not harm yourself
• Make rational decisions
• Follow established conventions
• Make rational progress towards goals
• Operate efficiently

• New software engineering paradigm
• Fault tolerance
• Provides graceful degradation
• Trustworthy systems

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PeroBase The Peromyscus Database at the
University of South Carolina
A Web-oriented Information System
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Envisioned Scope of PeroBase
Taxonomy, Systematics, Evolution
Genetics
Metabolism, Physiology, Biochemistry
Data and Bibliography
PeroBase
Reproduction, Development, Aging
Toxicology
Behavior
Vector Biology
Ecology
Population Biology