Nucleic Acids

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Nucleic Acids
Francis Harry Compton Crick
Great
Britain Institute of Molecular Biology
Cambridge,
Great Britain
1916 -
Maurice Hugh Frederick Wilkins Great
Britain University of London London, Great
Britain 1916 -
James Dewey Watson USA Harvard University Cambridg
e, MA, USA 1928 -
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Class of Nucleic Acids

• Deoxyribonucleic Acid (DNA)
• Nuclear DNA
• Cyclic DNA
• Mitochondrial DNA
• Ribonucleic Acid (RNA)
• Messenger (mRNA)
• Ribosomal (rRNA)
• Transfer (tRNA)

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The Nucleotide

• It is the building block of neuceic acids
• Its components are
• Nitrogen Bases
• Sugar
• Phosphate groups

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Nitrogen Bases

• Purines
• Adenine
• Guanine
• Peramidines
• Cytosine (DNA RNA)
• Thymine (Only in DNA)
• Uracil (Only in RNA)

DNA
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Sugars and Nucleotides

• Deoxyribose (DNA) GCAT
• Ribose (RNA) GCAU

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Deletion (1), duplication (2) and inversion (3)
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Gene Translocation
Acute Promyelocytic Leukemia (APL)
All-trans retinoic acid (ATRA) anthracycline
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Gene Deletion

• Velocardiofacial Syndrome (VCFS)

13q Deletion Syndrome
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Abnormal Number of Chromosomes
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Dawns Syndrome
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It is Bad Anyway
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Klinefelter and Turner Syndrome
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