ASTEROID Population at Baseline (n=507)

1
ASTEROID Population at Baseline (n507)
PatientsCompleting (n349) Patients NotCompleting (n158)
Age, years (mean) 58.5 58.5
Male 70.2 72.8
Weight, kg (mean) 85.5 86.2
Body mass index (median) 28.4 28.9
History of hypertension 96.0 93.7
History of diabetes mellitus 13.2 11.4
Concomitant Medications Concomitant Medications Concomitant Medications
Aspirin 83.7 83.5
ACE inhibitors 53.3 45.6
Angiotensin receptor antagonists 18.3 13.3
Organic nitrates 85.1 87.3
Beta-blockers 84.2 73.4
Nissen SE et al. JAMA 20062951556-1565.
2
Lipid Values and Percent Change (n346)
MeanBaseline Mean duringTreatment PercentChange pValue
Total cholesterol (mg/dL) 204.0 133.8 33.8 lt0.001
LDL-C (mg/dL) 130.4 60.8 53.2 lt0.001
HDL-C (mg/dL) 43.1 49.0 14.7 lt0.001
Triglycerides (mg/dL) 152.2 121.2 14.5 lt0.001
LDL-C/HDL-C ratio 3.2 1.3 58.5 lt0.001
Nissen SE et al. JAMA 20062951556-1565.
3
Dual Primary IVUS Efficacy Parameters
Median Change in Percent Atheroma Volume
Median Change in Most Diseased Subsegment
Change in Percent Atheroma Volume ()
Change in Percent Atheroma Volume (mm3)
5.6
0.79
Regressionplt0.001
Regressionplt0.001
Wilcoxon signed rank test for comparison with
baseline
Nissen SE et al. JAMA 20062951556-1565.
4
Recent Coronary IVUS Progression Trials
Relationship Between LDL-C and Progression Rate
CAMELOTplacebo
REVERSALpravastatin
ACTIVATEplacebo
Median Change in Percent Atheroma Volume ()
REVERSALatorvastatin
A-Plusplacebo
R2 0.95plt0.001
ASTEROIDrosuvastatin
Mean LDL-C (mg/dL)
Nissen SE et al. JAMA 20062951556-1565.