Structure of the transcriptional regulatory network

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Structure of the transcriptional regulatory
network
Madan Babu M, Luscombe N, Aravind L, Gerstein M
Teichmann SA Current Opinion in Structural
Biology (2004)
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Dynamic nature of the regulatory network in yeast
How are the networks used under different
conditions?
Are there differences in the sub-networks under
different conditions?
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The systems biology challenge
Genome sequence
Expression state
tigr.org
Alter, et al., PNAS, 2000
Physical interactions
Transcription factor binding
Palsson, Price, Papin, Trends Biotechnol., 2003
Cellular network
Palsson et al., Trends Biotechnol. 2004
Ren, et al., Science, 2000
Jason A. Papin, Ph.D. Department of Biomedical
Engineering University of Virginia
Bader, et al., Nat. Biotechnol., 2003
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Dynamic Modeling Computer Simulation
Mike Ellison Inst. Biomolecular Design Dept.
Biochemistry University of Alberta