Introducing Freshmen to Drug Delivery

1
Introducing Freshmen to Drug Delivery

• Stephanie Farrell and Robert P. Hesketh
• Chemical Engineering
• Rowan University

ASEE Annual Conference, June 2000
2
Drug Delivery

• Exciting multidisciplinary field
• Medicine, pharmaceutical sciences, chemistry,
  chemical engineering
• What role do chemical engineers play?

3
Introduction

• This experiment was used in
• Freshman Clinic
• Required of all freshmen
• 1 3-week module in each discipline
• Common thread measurements
• Graduate / Senior Elective
• Apply concepts of drug delivery and model
  development

4
Overview

• Introduction to drug formulations
• Experiment
• Measurements
• Data analysis

5
Drug Delivery

• Rate
• Duration
• Location, location, location

6
Rate and Duration of Release

• Contac? 12 hr cold capsules
• membrane system
• oral osmotic

7
Location Location Location

• Enteric-coated aspirin

Stomach pH 2 HCl
Intestine pH 8 NaOH
8
Lozenge Formulations

• Topical anaesthetics
• Pain relief
• Antifungal agents
• CNS depressants

• Sore throat
• Cancer
• Aids
• Depression
• Parkinsonism

9
Experiment
Cherry Cough Drop
Menthol (7.6 mg) red dye
Md mass of dissolved drug
M0 initial mass 7.6 mg
M mass remaining
10
Measurement
Samples
Spectrophotometer
Concentration
11
Data Analysis

• Model
• M07.6 mg
• Md from measurement
• Need to determine ?

12
Does It Make Sense?

• What does the model tell us?

Md(t 0) 0
Md(t ?) M0 7.6 mg
13
Parameter Evaluation

• Linear form
• Plot with Excel
• Use Trendline
• Slope ?

14
Data Representation

• Use model to calculate Md
• Compare with Experimental Data

15
Conclusion

• Introduction to drug delivery
• Chemical engineering principles
• Simple, visual experiment
• Concentration measurement
• Excel, data analysis, parameter evaluation
• Compare data with model

16
Feedback

• I enjoyed last night's class immensely. It was
  a practical approach to tying in many of the
  concepts we've been learning, with a twist of
  fun. Cool.
• James Downing, MSE candidate