The Benefits of Network Working STROKE RESEARCH

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The Benefits of Network WorkingSTROKE RESEARCH

• Tom Robinson
• Director, Trent SRN

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Talk Outline

• Stroke Research Network
• UK
• Trent
• Benefits
• Trialist
• Patient
• Working with CLRNs

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UK Stroke Research Network
Professor Gary Ford Director, UKSRN
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Trent Stroke Research Network
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Objective

• To facilitate the conduct of randomised
  prospective trials and other well-designed
  studies of stroke, including those for
  prevention, diagnosis and treatment

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Aims
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Research Themes

• Acute
• E.g. Blood pressure, Thrombolysis
• Community
• E.g. Carer Training
• Prevention
• E.g. Anticoagulation, Genetics, Vitamin
  replacement
• Rehabilitation
• E.g. OT, Psychology, SLT

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Adopted Trials

• 49 studies within the SRN study portfolio
• 4 commercial and 45 non-commercially sponsors
• 5 in set-up 32 recruiting 12 closed/in
  follow-up
• Research strands
• 10 acute studies
• 16 prevention studies
• 3 primary care studies
• 16 rehabilitation studies
• 1 joint acute / rehabilitation study
• 1 joint primary care / rehabilitation study
• 1 joint prevention / primary care study
• 1 translational research study
• March 2008

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UK SRN Patient Accrual
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UK SRN Active Sites
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Benefit Academic vs. Industry
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Example 1 Academic Trial
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Other Academic Trials

• gt 100 increase ACT-NOW BUCS ENOS
• gt 50 increase CLOTS VITATOPS
• gt 30 increase IST-3
• Unchanged BOTULS COSSACS ICSS
  DNA Lacunar, BSWISS

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Example 2 Industry Trial

• International, multi-centre, phase 3, randomised,
  double-blind stroke prevention study
• SRN support to study
• Site selection
• LRN support for recruitment
• Performance management and motivation
• Results
• Recruitment shown a significant, sustained
  increase
• UK target exceeded ahead of time
• Majority of participants came from SRN sites and
  the top 10 recruiters are affiliated to the
  network

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Example 2 Industry Trial
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Benefit Accrual
SRN
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Benefit Active Sites
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Portfolio BalanceThemes
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Portfolio BalanceSingle(s) vs Multi(m)-centre
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Patient and Public Development

• PCPI Clinical Study Group strategy and plan
  implemented
• Recruited 15 lay members to other 7 Clinical
  Study Groups
• Attended induction and training all will attend
  UK Stroke Forum
• Contributed to DH consultations research bids
  research workshops speakers at conferences
• 37 lay members in LRNs supported by network leads
  and managers
• Two proposed studies led by PCPI group

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Clinical Development

• Improved clinical infrastructure and service
  organisation to support research
• New research opportunities Hyperacute care
  stroke/TIA Social and community care
• Assoc Director Service Development now Clinical
  Director Clinical Network
• Clinical and Research Networks need to develop
  close links

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Cumbria and Lancashire
North West
Northumberland, Tyne and Wear
North East
Greater Manchester
County Durham and Tees Valley
Cheshire and Merseyside
North East Yorkshire and Northern Linconshire
Yorkshire
West Yorkshire
South Yorkshire
Trent
West Midlands (North)
Trent
West Midlands
Bham and the Black Country
Leicestershire, Ntonshire Rutland
West Midlands (South)
Norfolk and Suffolk
Bedfordshire and Cambridgeshire
Thames Valley
London (North West)
Thames
London (North East and North Central)
Western
Essex and Hertfordshire
London (South)
Peninsula
Peninsula
South East
Kent and Medway
Surrey and Sussex
Hampshire and Isle of Wight
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CLRN Working

• Joint CRO Appointments
• Clinical Investigator Sessions
• Training/ Events
• Costs

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Conclusion