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Atherosclerosis, Lifestyles, Lipoproteins

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Title: Atherosclerosis, Lifestyles, Lipoproteins


1
Atherosclerosis, Lifestyles,
Lipoproteins the Liver Sieve.
Sydney
Christchurch
(Social determinants of
death)
Size does matter
R Fraser, B Dobbs, H Jamieson, V Cogger, S
Hilmer, A Warren, E Latimer-Hill, R Cheluvappa, D
Le Couteur
2
Lifestyles, Liver Sieve, Lipoproteins
Death
  • EXCESS ALCOHOL
  • FREE RADICALS
  • NITROSAMINE
  • SURFACTANT
  • SEROTONIN
  • ENDOTOXIN
  • NICOTINE
  • HEPATITIS
  • DIABETES
  • OLD AGE
  • WORRY

3
Normal artery
Atherosclerosis
4
Glagov
5
Cholesterol-fed rabbits small intestinal
lymphatic lacteals
6
A Low Fat
A Low Fat
B C D High Fat High
Fat Low Fat
TDL emulsions of chylomicrons from rabbit after
feeding cholesterol
7
Chylomicrons A/D Low Fat Diet
Chylomicrons
Chylomicron
B/C High Fat Diet - Remnants
8
Nutmeg Liver
9
Enonymus pendulus
Rat portal vein cast
Alessandra Warren
Beale 1880s
10
Wisse
11
Wisse
12
(No Transcript)
13
Rabbit (NZ white)
Rat
Chicken
14
Rabbit coronary artery
15
Normal rabbit
Pantethine rabbit
16
Normal rat
Nicotine rat
17
Human cirrhosis
18
Human alcoholic hepatic sinusoid
19
Cirrhotic liver DMN Rat
20
Bernard Tamba-Lebbie
21
DMN for 9 days
No DMN for next 9 days
22
(No Transcript)
23
Factors Decreasing the Porosity of the Liver
Sieve
  • EXCESS ALCOHOL
  • FREE RADICALS
  • NITROSAMINE
  • SURFACTANT
  • SEROTONIN
  • ENDOTOXIN
  • NICOTINE
  • HEPATITIS
  • DIABETES
  • OLD AGE
  • WORRY

24
GENETIC DETERMINANTS OF ATHEROGENISIS
Apolipoprotein E2 Chch
25
(No Transcript)
26
LIFESTYLES in
TANDEM with GENES
controls hepatic synthesis of cholesterol by HMG
CoA reductase
27
CULTURAL EVOLUTION
  • The human trick of passing on new behaviours is
    called Cultural Evolution.
  • It lies behind the way fashion has shaped
    humanity.
  • Ideas travel faster than genes.
  • Peter Macinnnis
  • Mr Darwins incredible
    shrinking world

28
Chylomicrons and Sieves in Brisbane 2009
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