Title: Atherosclerosis, Lifestyles, Lipoproteins
1 Atherosclerosis, Lifestyles,
Lipoproteins the Liver Sieve.
Sydney
Christchurch
(Social determinants of
death)
Size does matter
R Fraser, B Dobbs, H Jamieson, V Cogger, S
Hilmer, A Warren, E Latimer-Hill, R Cheluvappa, D
Le Couteur
2Lifestyles, Liver Sieve, Lipoproteins
Death
- EXCESS ALCOHOL
- FREE RADICALS
- NITROSAMINE
- SURFACTANT
- SEROTONIN
- ENDOTOXIN
- NICOTINE
- HEPATITIS
- DIABETES
- OLD AGE
- WORRY
3 Normal artery
Atherosclerosis
4Glagov
5Cholesterol-fed rabbits small intestinal
lymphatic lacteals
6A Low Fat
A Low Fat
B C D High Fat High
Fat Low Fat
TDL emulsions of chylomicrons from rabbit after
feeding cholesterol
7Chylomicrons A/D Low Fat Diet
Chylomicrons
Chylomicron
B/C High Fat Diet - Remnants
8 Nutmeg Liver
9Enonymus pendulus
Rat portal vein cast
Alessandra Warren
Beale 1880s
10 Wisse
11 Wisse
12(No Transcript)
13 Rabbit (NZ white)
Rat
Chicken
14 Rabbit coronary artery
15Normal rabbit
Pantethine rabbit
16 Normal rat
Nicotine rat
17 Human cirrhosis
18Human alcoholic hepatic sinusoid
19Cirrhotic liver DMN Rat
20 Bernard Tamba-Lebbie
21DMN for 9 days
No DMN for next 9 days
22(No Transcript)
23Factors Decreasing the Porosity of the Liver
Sieve
- EXCESS ALCOHOL
- FREE RADICALS
- NITROSAMINE
- SURFACTANT
- SEROTONIN
- ENDOTOXIN
- NICOTINE
- HEPATITIS
- DIABETES
- OLD AGE
- WORRY
24GENETIC DETERMINANTS OF ATHEROGENISIS
Apolipoprotein E2 Chch
25(No Transcript)
26 LIFESTYLES in
TANDEM with GENES
controls hepatic synthesis of cholesterol by HMG
CoA reductase
27CULTURAL EVOLUTION
- The human trick of passing on new behaviours is
called Cultural Evolution. - It lies behind the way fashion has shaped
humanity. - Ideas travel faster than genes.
- Peter Macinnnis
- Mr Darwins incredible
shrinking world
28Chylomicrons and Sieves in Brisbane 2009