ESFRI Roadmap of Research Infrastructures and the Israeli Perspective

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ESFRI Roadmap of Research Infrastructuresand the
Israeli Perspective

• David Horn, Tel Aviv University
• http//horn.tau.ac.il
• July, 2009

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General information

• ESFRI, the European Strategy Forum on Research
  Infrastructures, is a strategic instrument to
  develop the scientific integration of Europe and
  to strengthen its international outreach.
• Founded in 2002. Members nominated by Member and
  Associate countries.
• The mission of ESFRI is to support a coherent and
  strategy-led approach to policy-making on
  research infrastructures in Europe, and to
  facilitate multilateral initiatives leading to
  the better use and development of research
  infrastructures, at EU and international level.
• Publication of first roadmap in 2006, and second
  roadmap in 2008.
• Roadmaps are used by DG research as basis of
  appropriate calls for RI projects.

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Roadmap structure

• Social Sciences and Humanities
• Environmental Sciences
• Energy
• Biological and Medical Sciences
• Materials and Analytical Facilities
• Physical Sciences and Engineering
• e-Infrastructures

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Social Sciences andHumanities

• European Social Survey
• Upgrade of the European Social Survey, set up in
  2001 to monitor longterm changes in social values
• Costs construction 54M, operation 9M.
• (Noah Levin-Epstein, TAU)
• SHARE
• Data infrastructure for empiric economic and
  social science analysis of ongoing changes due to
  population ageing
• Costs 11.6M, 0.3M.
• (Howie Litwin, HU)

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Biological and MedicalSciences

• BBMRI
• Bio-banking and biomolecular resources research
  infrastructure
• Costs 170M, 15M.
• (INTB, Ciechanover et al ?)
• INSTRUCT
• Integrated Structural Biology Infrastructure
• Costs 300M, 25M.
• (Joel Sussman, WIS)
• ELIXIR
• Upgrade of the European Life-science
  infrastructure for biological information
• Costs470M, 100M.
• (Michal Linial, HUJ, MoS)

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BBMRI Biobanking and Biomolecular Resources
Research Infrastructure

• EC 5 M
• 27 months 50 participants
• BBMRI will comprise
• all major population-based and disease-oriented
  biobank formats
• Biomolecular resources, such as collections of
  antibodies and other affinity binders and a
  variety of molecular tools to decipher protein
  interactions and function
• bio-computing and sample storage infrastructure.
• BBMRI will provide
• Biobanks of different formats (based on
  collections of DNA, tissue, cells, blood and
  other body fluids, together with pertinent
  medical, environmental, life-style and follow-up
  data)
• Population cohorts, including prospective and
  twin cohorts
• Clinical case/control cohorts including
  disease-focused cohorts
• Cohorts from isolated populations
• Biomolecular resources (comprising antibody and
  affinity binder collections, ORF clone
  collections, siRNA libraries, proteins, cellular
  resources etc.)
• Enabling technologies and high-throughput
  analysis platforms and integration of sites
  specialized in development of molecular tools to
  decipher gene, protein and metabolite functions
  and their interactions
• Harmonized standards for sample collection,
  storage, preanalytics and analysis
• Harmonized data collection, logistics and
  database- and biocomputing infrastructure
• Ethical, legal and societal guidance and
  platform.

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INSTRUCT Integrated Structural BiologyEC 4.5
M 24 months 13 partners

• The seven core centers comprising INSTRUCT are
• Core A University of Oxford, UK (Prof. Dave
  Stuart, Coordinator for INSTRUCT) -
  multi-disciplinary approaches.
• Core B CIRMMP Florence, Italy (Prof. Ivano
  Bertini) - NMR-based and integrated biophysical
  investigation of the structure and dynamics of
  biomolecules.
• Core C IGBMC Strasbourg, France (Prof. Dino
  Moras) - multi-scale structural biology of
  proteins, nucleic acids and their complexes.
• Core D The Weizmann Institute, Israel (Prof.
  Joel L. Sussman) - multidisciplinary resource
  (X-ray/NMR/EM) for elucidation of structure and
  dynamics.
• Core E EMBL (Dr. Stephen Cusack) - provide
  integrated structural biology infrastructures,
  including synchrotron X-ray and imaging
  technologies.
• Core F MPI Munich, Germany (Prof. Wolfgang
  Baumeister) - broad expertise in high-resolution
  3D imaging, with unique strength in using
  cryo-electron tomography.
• Core G MPI Frankfurt, Germany (Prof. Hartmut
  Michel) - integrated biophysical and structural
  analyses of macromolecular complexes, including
  membrane proteins.

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• ELIXIR Upgrade of European
• Bioinformatics Infrastructure
• EC 4.5 M
• 38 months
• 32 partners
• www.elixir-europe.org
• ELIXIR will permit the integration and
  interoperability
• of diverse, heterogeneous, potentially redundant
  information that is essential to generate and
  utilize biological knowledge. It will encompass
  the necessary major computer infrastructure to
  store and organize this data in a way suitable
  for rapid search and access, and will provide a
  sophisticated and user-friendly portal for users.

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Other

• ESRF Upgrade (Analytical Facilities)
• Upgrade of the European Synchrotron Radiation
  Facility
• Costs 238M, 83M
• EPOS (Environmental Sciences)
• Infrastructure for the study of tectonics and
  Earth surface dynamics
• Costs 500M, 80M
• LIFEWATCH (Environmental Sciences)
• Infrastructure for research on the protection,
  management and sustainable use of biodiversity
• Costs 370M, 71M

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Swedish research infrastructures

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Swedish research infrastructures - continued



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Finlands example
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Finlands example
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Relevant current IL RI funding

• ESRF, funded by TELEM since 1999. Current annual
  funding (mostly by VATAT) is roughly 1M euro.
• Geant, internet infrastructure, funded by TELEM
  1999-2002. Ongoing funding by universities
  through IUCC (machba).
• ISRAGRID, novel e-infrastruture, funded by TELEM
  2009-2013. Will become part of european grid
  initiative.
• EMBLEMBC, funded by MOS. Annual costs 0.9 M
  euro. Relevant to ELIXIR, the proposed EBI
  upgrade.
• ESS, vatat funds 200K2 years.

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Israels RI Roadmap

• Israels strategy is being planned by VATAM, the
  Israel Committee for National Research
  Infrastructures
• VATAM was established by MOLMOP, the Israel
  National Council for Research and Development
• VATAM serves as an advisory board to governmental
  agencies (including TELEM) on questions regarding
  RIs.
• MOLMOP has called for the establishment of a
  national fund dedicated to RI, aiming for annual
  expenditures of 100 M NIS.
• VATAM has started a national RI survey, carried
  out by the Neeman institute of the Technion.
  This survey will serve as the basis for future
  planning of an RI roadmap.
• See http//horn.tau.ac.il/vatam.html for further
  information