(PDF) Robustness and Evolvability in Living Systems (Princeton Studies in Complexity) Full

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Description
All living things are remarkably complex, yet
their DNA is unstable, undergoing countless
random mutations over generations. Despite this
instability, most animals do not grow two heads
or die, plants continue to thrive, and
bacteria continue to divide. Robustness and
Evolvability in Living Systems tackles
this perplexing paradox. The book explores why
genetic changes do not cause organisms to fail
catastrophically and how evolution shapes
organisms' robustness. Andreas Wagner looks at
this problem from the ground up, starting with
the alphabet of DNA, the genetic code, RNA, and
protein molecules, moving on to genetic networks
and embryonic development, and working his way up
to whole organisms. He then develops an
evolutionary explanation for robustness. Wagner
shows how evolution by natural selection preferent
ially finds and favors robust solutions to the
problems organisms face in surviving and
reproducing. Such robustness, he argues, also
enhances the potential for future evolutionary
innovation. Wagner also argues that robustness
has less to do with organisms having plenty of
spare parts (the redundancy theory that has been
popular) and more to do with the reality
that mutations can change organisms in ways that
do not substantively affect their fitness.
Unparalleled in its field, this book offers the
most detailed analysis available of all facets of
robustness within organisms. It will appeal not
only to biologists but also to engineers
interested in the design of robust systems and to
social scientists concerned with robustness in
human communities and populations.
3
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Description
All living things are remarkably complex, yet
their DNA is unstable, undergoing countless
random mutations over generations. Despite this
instability, most animals do not grow two heads
or die, plants continue to thrive, and bacteria
continue to divide. Robustness and Evolvability
in Living Systems tackles this perplexing
paradox. The book explores why genetic changes do
not cause organisms to fail catastrophically and
how evolution shapes organisms' robustness.
Andreas Wagner looks at this problem from the
ground up, starting with the alphabet of DNA, the
genetic code, RNA, and protein molecules, moving
on to genetic networks and embryonic development,
and working his way up to whole organisms. He
then develops an evolutionary explanation for
robustness. Wagner shows how evolution by
natural selection preferentially finds and favors
robust solutions to the problems organisms face
in surviving and reproducing. Such robustness, he
argues, also enhances the potential for future
evolutionary innovation. Wagner also argues that
robustness has less to do with organisms having
plenty of spare parts (the redundancy theory that
has been popular) and more to do with the reality
that mutations can change organisms in ways that
do not substantively affect their fitness.
Unparalleled in its field, this book offers the
most detailed analysis available of all facets of
robustness within organisms. It will appeal not
only to biologists but also to engineers
interested in the design of robust systems and to
social scientists concerned with robustness in
human communities and populations.
6
(PDF) Robustness and Evolvability in Living
Systems (Princeton Studies in Complexity) Full