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Antibiotics Challenges, Mechanisms,
Opportunities (ASM Books Book 30)
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Antibiotics Challenges, Mechanisms,
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Description
A chemocentric view of the molecular structures
of antibiotics, their origins, actions, and major
categories of resistanceAntibiotics Challenges,
Mechanisms, Opportunities focuses on antibiotics
as small organic molecules, from both natural and
synthetic sources. Understanding the chemical
scaffold and functional group structures of the
major classes of clinically useful antibiotics is
critical to understanding how antibiotics
interact selectively with bacterial targets.This
textbook details how classes of antibiotics
interact with five known robust bacterial
targets cell wall assembly and maintenance,
membrane integrity, protein synthesis, DNA and
RNA information transfer, and the folate pathway
to deoxythymidylate. It also addresses the
universe of bacterial resistance, from the
concept of the resistome to the three major
mechanisms of resistance antibiotic destruction,
antibiotic active efflux, and alteration of
antibiotic targets. Antibiotics also covers the
biosynthetic machinery for the major classes of
natural product antibiotics.Authors Christopher
Walsh and Timothy Wencewicz provide compelling
answers to these questionsWhat are
antibiotics?Where do antibiotics come from?How do
antibiotics work?Why do antibiotics stop
working?How should our limited inventory of
effective antibiotics be addressed?Antibiotics is
a textbook for graduate courses in chemical
biology, pharmacology, medicinal chemistry, and
microbiology and biochemistry courses. It is also
a valuable reference for microbiologists,
biological and natural product chemists,
pharmacologists, and research and development
scientists.