The Link between Gut Health, Fasting, and Autoimmune Diseases

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The Link between Gut Health, Fasting, and
Autoimmune Diseases
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The Link between Gut Health, Fasting, and
Autoimmune Diseases

• Prevalence and Types of Autoimmune Diseases
• Autoimmune disease affects hundreds of millions
  of people worldwide, and its prevalence is
  increasing.
• There are 100 known autoimmune disease types.
• Some of the more prevalent include type 1
  diabetes, rheumatoid arthritis (RA), systemic
  lupus erythematosus (SLE), and inflammatory bowel
  disease (IBD)

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• Chronic Inflammation and Triggers
• For a patient with a history of chronic systemic
  inflammation and an antecedent, like an
  inflammatory diet or a psychological stressor
  could act as a trigger to precipitate autoimmune
  disease or disease flare-up.

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The Link between Intestinal Permeability and
Autoimmune Diseases

• Genetic and environmental factors have long been
  understood to trigger autoimmune disease.
• In 2000, a third elementintestinal permeability
  commonly known as leaky gut which allows passage
  of antigensmacromolecules, toxins, food
  proteins, or othersfrom the gut into the body
  intestinal permeability was found, Zonulinis the
  master regulator of intestinal permeability that
  opens the door to several chronic inflammatory
  conditions.
• Zonulin is found in abundance in rheumatoid
  arthritis, systemic lupus erythematosus,
  irritable bowel syndrome, and other autoimmune
  diseases Using zonulin as a biomarker for leaky
  gut is linked to age-related inflammation and
  frailty (decreased muscle strength).
• Pathogenic bacteria and gliadin are major
  triggers that cause the release of zonulin.
  Lactobacillus rhamnosus GG inhibits gliadin from
  altering intestinal permeability.
• This research contributes to a growing body of
  evidence showing the efficacy of healthy bacteria
  in treating the chronic inflammation implicated
  in autoimmune diseases.
• 
  
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Gut Microbiome and Chronic Diseases

• Dysbiosis of gut microbiota has been closely
  linked to several diseases, such as obesity, type
  2 diabetes, hypertension, necrotizing
  enterocolitis, and inflammatory bowel diseases.
• Healthy lifestyle factors, including a
  diversified diet, limited consumption of
  processed and refined foods, and consumption of
  adequate dietary fiber, may all promote a healthy
  microbiome.
• Foods and nutrients that potentially boost immune
  function also tend to promote gut health.
• For example, consuming a diverse array of fruits
  and vegetables rich in antioxidants,
  anti-inflammatory nutrients, and phytochemicals
  may reduce oxidative stress, support the liver to
  promote efficient biotransformation and
  detoxification, and boost overall immune system
  function.

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Strategies for Managing Autoimmunity

• Fasting is the fastest way to bring autoimmunity
  under control. After 72 hours of water-only
  fasting, autophagy and apoptosis changed in a
  favorable direction.
• In addition, components of the innate immune
  system were boosted compared to baseline
  measurements.
• Timed eating is another way to benefit the immune
  system. Timed eating is where you consume three
  meals per day within an eight-hour time frame at
  1 pm, 4 pm, and 8 pm.
• After 12 months of TRE, inflammatory markers
  (interleukin 6, interleukin 1-beta, and
  TNF-alpha) were reduced, and both insulin
  sensitivity and lipid profiles were significantly
  improved compared to controls.
• Intermittent fasting enhances beneficial gut
  bacteria and increases short-chain fatty acids
  that promote healthy immune function. Please
  consult with your physician before engaging in
  any kind of fasting routine as the extent of
  fasting and support during fasting should be
  personalized for optimum outcome.

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• Thank You

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